Proproten-100 (Proproten-100)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceAntibodies to the brain-specific protein S-100Antibodies to the brain-specific protein S-100
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    NPF Materia Medica Holding, OOO     Russia
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    NPF Materia Medica Holding, OOO     Russia
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    NPF Materia Medica Holding, OOO     Russia
    • Dosage form: & nbsplozenges
    Composition:Composition (per 1 tablet)
    Active substances:
    Antibodies to the brain-specific protein S-100 affinity purified - 0.003 g *.
    Excipients: lactose monohydrate 0.267 g, microcrystalline cellulose 0.03 g, magnesium stearate 0.003 g.
    * are applied to lactose in the form of a water-alcohol mixture with a content of not more than KG1991 ng / g of the active form of the active substance.
    Description:

    Tablets are flat-cylindrical, with a risk and chamfer, from white to almost white. On the flat side with the risk of inscription MATERIA MEDICA, on the other flat side there is an inscription PROPROTEN 100.

    Pharmacotherapeutic group:Alcoholism means treatment.
    ATX: & nbsp

    N.06.A.X   Other antidepressants

    Pharmacodynamics:

    The preparation modifies the functional activity of the protein S-100, carrying out in the brain conjugation of information and metabolic processes.Sensitizes the neuronal membrane, modulates the synaptic plasticity of the neurons. Has a modifying effect on the functional state of the brain structures involved in the formation of alcohol dependence: the hypothalamus, the hippocampus, etc. With alcohol dependence, it has a normalizing effect on the system of positive emotional reinforcement, which leads to a decrease in the frequency of self-stimulation of the lateral hypothalamus. Reduces the bursting activity of neurons in the hippocampus; reduces the number of circulating immunocomplexes in the peripheral blood, which correlates with a decrease in ethanol consumption. Helps enhance the inhibitory effects of GABA in the central nervous system. It has been experimentally established that the drug restores the neurotransmitter balance and conditioned reflex activity. Increases brain resistance to hypoxia and to toxic effects.

    Indications:It shows an anti-alcohol effect, reducing the craving for alcohol and reducing the likelihood of relapse.

    Monotherapy for alcoholic withdrawal syndrome of mild and moderate severity. The drug facilitates both psychopathological disorders (anxiety, mental stress, insomnia, irritability,anxiety, mood reduction, intense attraction to alcohol), and somatovegetative disorders (weakness, sweating, headache, tremor, tachycardia, digestive disorders) alcoholic "hangover" syndrome.
    Contraindications:

    Increased individual sensitivity to the components of the drug, pregnancy and lactation.

    Dosing and Administration:At one time - 1 tablet to keep in your mouth until completely dissolved - (not during meals).

    In a hangover state, the first 2 hours of the drug take 1 tablet every 30 minutes; the next 8-10 hours - 1 tablet per hour. In case of sleep, the reception is resumed upon awakening.
    In the future, when the condition improves, the drug is taken 1 tablet every 2 to 3 hours (4-6 tablets per day) for 2-3 days. When weighting the symptoms of alcohol withdrawal, it is necessary to attach medications traditionally used in detoxification.

    For the prevention of relapse, the drug is taken 1-2 tablets per day for 2 -3 months; after accidental consumption of alcohol take an additional 2 tablets of the drug 2 times - in the afternoon and at night.

    Side effects:Possible reactions of increased individual sensitivity to the components of the drug.
    Overdose:In case of an accidental overdose, dyspepsia is possible due to the excipients included in the formulation.
    Interaction:

    Cases of incompatibility with other drugs have not been identified to date.

    Special instructions:The composition of the drug includes lactose monohydrate, and therefore it is not recommended for patients with congenital galactosemia, glucose malabsorption syndrome, or with congenital lactase insufficiency.
    Form release / dosage:Lozenges.
    Packaging:For 20 tablets in a planar cell packaging made of polyvinylchloride film and aluminum foil.
    For 1, 2 or 5 contour mesh packages together with the instruction for medical use are placed in a pack of cardboard.
    Storage conditions:At a temperature of no higher than 25 ° C.
    Keep out of the reach of children.
    During the period of application of the preparation, store the contour mesh package in a cardboard bundle provided by the manufacturer.
    Shelf life:

    3 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N002352 / 01
    Date of registration:30.04.2008
    The owner of the registration certificate:NPF Materia Medica Holding, OOO NPF Materia Medica Holding, OOO Russia
    Manufacturer: & nbsp
    Representation: & nbspNPF Materia Medica Holding LLC NPF Materia Medica Holding LLC Russia
    Information update date: & nbsp17.01.2013
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