Side effects of protionamide are manifested from the gastrointestinal tract, liver, skin, endocrine and nervous system.
From the digestive system: loss of appetite, nausea, vomiting, diarrhea, dryness or hypersalivation, metallic taste in the mouth. After the withdrawal of the drug, these phenomena tend to quickly pass.
Often during the treatment there is a rise in the blood level of transaminases.Rare violations of liver function with signs of hepatitis and jaundice are rare. Hepatotoxicity of the drug depends on the existing violations of the liver, such as liver damage due to alcoholism or postoperative interventions. These side effects are noted especially in combination therapy with isoniazid, rifampicin and pyrazinamide.
Skin Reactions are rare, in some cases described pellagrope-like reactions, respectively, with a combination of skin manifestations and disorders from the central nervous system.
Sometimes noted endocrine system disorders. Along with the development of hypoglycemia (a decrease in blood sugar of less than 50 mg%) in diabetic patients, the development of gynecomastia (an increase in mammary glands in men) is described. Rarely there is a violation of the menstrual cycle and impotence, as well as hypothyroidism (a decrease in the functions of the thyroid gland).
From the nervous system: insomnia, agitation, depression, anxiety, rarely - dizziness, drowsiness, headache, weakness, impaired concentration, mental disorders, in single cases - paresthesia. Rarely, optic neuritis.In some cases, allergic reactions and disorders of the bone marrow are described.
From the cardiovascular system: tachycardia, orthostatic hypotension.