Proxopheline @ (Proxophelin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspEye drops.
Composition:1 ml of the solution contains:
Active substances:
bugylaminohydroxypropoxyphenoxymethyl methyl oxadiazole hydrochloride-10.00 mg,
clonidine hydrochloride (clonidine) - 2.50 mg
Excipients:
benzethonium chloride - 0.10 mg,
sodium chloride - 6.00 mg,
citric acid monohydrate (or citric acid in terms of citric acid monohydrate) - 0.33 mg,
sodium citrate pentasecylhydrate - 6.49 mg,
water for injection - up to 1 ml.
Description:Transparent colorless or slightly colored liquid.
Pharmacotherapeutic group:Antiglaucoma means
ATX: & nbsp
  • Other antiglaucoma drugs
    • Pharmacodynamics:

    Combined drug, has anti-glaucoma effect.
    Clonidine and butylamine hydroxypropoxyphenoxymethyl methyl oxadiazole: reduce intraocular pressure by reducing the production of aqueous humor and increasing its outflow.
    The effect comes in 15-30 minutes after the instalthe maximum reaches 2-6 hours and remains for 24 hours. Does not affect the accommodation, refraction and the size of the pupil.

    Pharmacokinetics:Local drug - pharmacodynamics has not been studied.
    Indications:

    Proxopheline is used to reduce intraocular pressure in patients with various forms of glaucoma (open-angle, closedgsecondary, secondary in the case of insufficient effect of monotherapy with proxodolol or clofewhetherbutm. In closed-angle glaucoma, the drug is used in combination with miotics.

    Contraindications:

    - individual hypersensitivity to the components of the drug;

    - bronchial asthma;

    - chronic obstructiontlung disease;

    - Chronic heart failure;

    bradycardia;

    - atrioventricular block II-III p.

    - arterial hypotension;

    - Pregnancy;

    - Children's age (there is no sufficient experience of using the drug in children).

    Carefully

    Diabetes mellitus type 1, peptic ulcer and 12the rectum.
    Carefully:During the treatment with the drug, it is not recommended to wear soft contact lenses. When using hard lenses, they should be removed before instillation and re-worn through 15-20 minutes after the installation of the drug.
    Pregnancy and lactation:

    During pregnancy, it is necessary to compare the benefits to the mother and the risk to the fetus and newborn. It is not known whether the drug penetrates into breast milk, so it is recommended that breastfeeding be canceled during the lactation period, at the time of treatment.

    Dosing and Administration:The drug is instilled in the conjunctival sac of the eye Pabout 1 drop 2 times a day.Apply in the form of monotherapy and in combination with pilocarpine, which is instilled 1-3 times a day.
    Side effects:

    In isolated cases, possible: lowering blood pressure, slowing the heart rate, dry mouth, drowsiness, weakness, dizziness, but to a lesser extent than from the use of one clonidine.

    Overdose:Increased side effects.
    Treatment: cancellation of the drug.
    Interaction:

    CombinationsMr.The use of 1% pilocarpine solution causes an additional hypotensive effect on the level of intraocular pressure (IOP).
    With the simultaneous administration of systemic alpha or beta-blockers, it is possible to intensify the hypotensive effect.

    Special instructions:

    The dropper should be closed after each use. Do not touch the tip of the tube to the eye.

    Effect on the ability to drive transp. cf. and fur:

    Patients who temporarily lose visual clarity after installation, it is not recommended to drive or work with complicated equipment, machines or any other complicated equipment that requires clear vision immediately after instillation of the drug.

    Form release / dosage:Eye drops.
    Packaging:1.5 ml, 2 ml or 5 ml in a tube-dropper polymer.
    1, 2, 4, 5 or 10 tubes with instructions for the use of the drug in a pack of cardboard.
    5 ml or 10 ml into the bottle-dropper polymer.
    1 or 2 vials of a dropper with instructions for the use of the drug in a pack of cardboard.
    The text of the instruction for the use of a tube-dropper or a bottle-dropper is applied to the pack.
    Storage conditions:

    In the dark place at a temperaturetno higher than 15 FROM. Keep out of the reach of children.

    Shelf life:

    2 years.
    Shelf life after the opening - 1 month.
    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-002629/07
    Date of registration:07.09.2007 / 31.08.2015
    The owner of the registration certificate:MOSCOW ENDOCRINE FACTORY, FSUE MOSCOW ENDOCRINE FACTORY, FSUE Russia
    Manufacturer: & nbsp
    Representation: & nbspMOSCOW ENDOCRINE FACTORY FGUP MOSCOW ENDOCRINE FACTORY FGUP Russia
    Information update date: & nbsp2016-03-10
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