Senadexin (Senadexine)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsppills
Composition:

In 1 tablet:

active ingredient: calcium sennosides 20% - 70 mg.

Excipients: lactose monohydrate, corn starch, vanillin, magnesium stearate, methylparahydroxybenzoate (nipagin), stearic acid, talc, microcrystalline cellulose, croscarmellose sodium.

Description:

Tablets of flat-cylindrical form, with a risk and facet, from gray-brown to brown with impregnations of a darker and lighter color, with the smell of vanillin.

Pharmacotherapeutic group:laxative herbal remedy
ATX: & nbsp
  • Senna glycosides
    • Pharmacodynamics:

    Laxative product of plant origin (senna leaf or Alexandrian leaf, or cassia leaf holly).

    The pharmacological action is due to anthraglikozidami (mainly sennozidami A and B), as well as other glycosides. When used internally, the senna glycosides pass through the stomach and small intestine unchanged, not absorbed. In the large intestine, the anthroglycosides are digested by intestinal bacteria into pharmacologically active anthrons and anthranoles, which irritate the intestinal receptors of the colon, increase peristalsis, and accelerate the evacuation of the intestine.Antrons and anthranols interfere with the absorption of water and electrolytes, promote the diffusion of water into the lumen of the intestine.

    Due to the osmotic effect, loosening of the stool masses and increasing their volume, contributing to the relaxing effect of anthraglycosides.

    The laxative effect is manifested after 6-10 hours. With prolonged use of the drug, its intensity may decrease due to a decrease in the potassium content in the body.

    The drug is well tolerated by patients, due to the low content of resinous substances, it does not irritate the intestines.

    Pharmacokinetics:

    Metabolites of anthraglikozid senna are practically not absorbed, mainly they are excreted with feces, as well as with urine. Isolated with sweat, penetrate into breast milk.

    Indications:

    Chronic constipation, hypo- and atony of the intestine, facilitating the emptying of the intestine with hemorrhoids, proctitis and fissures of the anus, cleansing the bowel before the diagnostic and treatment procedures.

    Contraindications:

    - Increased individual sensitivity to senna preparations and other components of the drug;

    - Metrorrhagia, paralytic intestinal obstruction, acute inflammatory bowel diseases (Crohn's disease, ulcerative colitis, appendicitis), peritonitis, peptic ulcer of the stomach and duodenum, gastrointestinal bleeding, strangulated hernia, cystitis, abdominal pain of unknown genesis;

    - Severe violations of the water-electrolyte balance;

    - Children under 1 year old.

    Carefully:

    Caution should be used in children under 6 years of age, in patients with liver and / or kidney disease.

    Pregnancy and lactation:

    The use of the drug in pregnant women is associated with a higher probability of developing side effects (abdominal pain, diarrhea). For the duration of treatment with the drug, breastfeeding should be discontinued, as the components of the drug can penetrate into breast milk and cause frequent loose stools in the infant.

    Dosing and Administration:

    Take inside, once a day, washing down with liquid. Adults and children over 12 years of age are prescribed at bedtime, children under 12 years of age - in the morning on an empty stomach.

    Adults and children over 12 years of age are prescribed 1-2 tablets; in the absence of effect, the dose is increased to 2-3 tablets per reception.The maximum daily dose is 3 tablets.

    Children aged 6 to 12 years are prescribed 1 tablet. The maximum daily dose is 2 tablets.

    Children aged 3 to 6 years are ½-1 tablet. The maximum daily dose is 1½ pills.

    Children aged 1 to 3 years are ½ pills. The maximum daily dose is 1 tablet.

    It should be used the smallest dose necessary for obtaining soft feces. When selecting a dose, the same dose should be used for several days, in the absence of effect - gradually increase the dose to ½ pills. If the maximum dose is not applied within three days of defecation, it is necessary to consult a doctor.

    At the course of application after two weeks of the drug should be taken a break in two weeks.

    Do not use for a long time or at doses exceeding recommended.
    Side effects:

    The drug is usually well tolerated, anorexia, abdominal pain, diarrhea, a change in urine color (red or brown), allergic reactions are rarely possible. With prolonged use, electrolyte loss, mainly potassium, meteorism, albuminuria, hematuria, intestinal pseudomelanosis, intestinal atony, digestive disorders are possible.

    Overdose:

    Overdose can lead to diarrhea, leading to violations of the water-electrolyte balance. In this case, you should cancel the drug. Treatment is symptomatic.

    Interaction:

    With long-term use or application in high doses, the drug enhances the effect of cardiac glycosides and antarctic agents due to a decrease in potassium in the body, disrupts the absorption of tetracyclines. With simultaneous use with thiazide diuretics, hormones of the adrenal cortex, drugs from licorice root, the risk of hypokalemia increases. Reduces the effectiveness of drugs that are slowly absorbed in the gastrointestinal tract.

    Special instructions:

    During treatment, acid urine can acquire a tan color, alkaline - a reddish color.

    The drug is recommended to be used only if normalization of the stool can not be achieved by changing the diet or using drugs that increase the volume of intestinal contents.

    Effect on the ability to drive transp. cf. and fur:

    The drug usually does not affect the management of vehicles and performance of works requiring increased attention, rapidity of mental and motor reactions.However, it is necessary to check the individual reaction to the drug.

    Form release / dosage:

    Tablets of 70 mg.

    Packaging:

    10 tablets per contour cell pack. For 1 or 2 contour mesh packages, together with instructions for medical use, put in a pack of cardboard.

    Storage conditions:In a dry, dark place at a temperature of 8 ° C to 25 ° C.
    Keep out of the reach of children.
    Shelf life:

    3 years. Do not use the product after the expiration date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:П N014675 / 01-2003
    Date of registration:28.04.2008 / 28.09.2011
    The owner of the registration certificate:HEALTH PHARMACEUTICAL COMPANY, LTD. HEALTH PHARMACEUTICAL COMPANY, LTD. Ukraine
    Manufacturer: & nbsp
    Information update date: & nbsp06.03.16
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