Hypersensitivity to the drug, perforated ulcer, intestinal obstruction, abdominal pain of unknown origin, disturbance of water-electrolyte metabolism, acute inflammatory diseases of the abdominal cavity organs, proctitis and hemorrhoids in the acute stage, strangulated hernia, bleeding from the gastrointestinal tract,uterine bleeding, cystitis, spastic colitis, spastic constipation, pregnancy, the period of breastfeeding, children under 12 years.