Hypersensitivity to the drug, perforated ulcer, intestinal obstruction, abdominal pain of unknown origin, disturbed water-electrolyte metabolism, acute inflammatory diseases of the abdominal cavity organs,proctitis and hemorrhoids in the stage of exacerbation, strangulated hernia, bleeding from the gastrointestinal tract, uterine bleeding, cystitis, spastic colitis, spastic constipation, pregnancy, lactation, children under 12 years.