Sinaflan (Sinaflan )

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspointment for external use
Composition:
100 g of ointment contains:
active substance: fluocinolone acetonide in terms of 100% substance - 0.025 g; auxiliary substances: propylene glycol 4.975 g, petrolatum 80 g, lanolin 5 g, paraffin hard 10 g. , .
Description:
Ointment from light yellow to yellow.

Pharmacotherapeutic group:Glucocorticosteroid for topical application
Pharmacodynamics:
Glucocorticosteroid for external use; inhibits the release of inflammatory mediators. When exposed to the skin, the edge accumulation of neutrophils is prevented, which leads to a decrease in inflammatory exudate and production of cytokines; inhibition of migration of macrophages, reduction of infiltration and granulation. Has anti-inflammatory and anti-allergic effect. : ’

Pharmacokinetics:
After absorption from the surface of the skin binds to plasma proteins, it is metabolized in the liver with the formation of inactive metabolites. It is excreted mainly by the kidneys.

Indications:
Inflammatory and allergic skin diseases of non-microbial etiology: eczema, atopic dermatitis, simple chronic lichen (limited neurodermatitis), itchy skin, psoriasis and other chronic diseases, accompanied by dry skin.

Contraindications:
Hypersensitivity, skin manifestations - syphilis, skin tuberculosis, diaper rash, rosacea, extensive psoriatic plaques, anogenital itching; skin infections,caused by bacteria, viruses, fungi - pyoderma, chicken pox, Herpes, actinomycosis, blastomycosis, sporotrichosis, trophic ulcers of the shin, associated with varicose veins, erosive and ulcerative lesions of the gastrointestinal tract, ulcer and wounds in the areas of applications, skin cancer , nevus, atheroma, melanoma, hemangioma, xanthoma, sarcoma, pregnancy, lactation period, children's age (up to 2 years).

Carefully:
At girls in puberty.

Dosing and Administration:
Outwardly. On the previously wiped with a tampon moistened with antiseptic liquid, the skin is applied a small amount of the drug 2-4 times a day and lightly rubbed. If necessary, you can impose an occlusive dressing, leaving it on the affected surface for 3-4 days: Do not apply under the bandage more than 2 g / day. - Duration of treatment depends on the nature of the disease and the effectiveness of therapy, usually 5-10 days; If the disease persists, the course of treatment can be extended to 25 days or more. Children are recommended to use the minimum effective dose, not more than 5 days.

Side effects:
Burning, itching, steroid acne, striae, dry skin, folliculitis. With prolonged use, skin atrophy, local hirsutism, hypertrichosis, telangiectasia, purpura, skin pigmentation disorders, alopecia, especially in women, secondary immunodeficiency (exacerbation of chronic infectious diseases, generalization of the infectious process, development of opportunistic infections); when applied to large surfaces, systemic manifestations are possible (gastritis, steroid stomach ulcer, adrenal insufficiency, Itenko-Cushing syndrome, steroid diabetes mellitus, slowing of reparative processes).

Overdose:
itching and burning of the skin at the site of application, hyperglycemia, glucosuria, Itenko-Cushing syndrome.
Treatment: symptomatic on the background of a gradual withdrawal of the drug.
Interaction:
Compatible with antimicrobial drugs.
Reduces the activity of antihypertensive, diuretic, antiarrhythmic drugs, potassium preparations.
Diuretic medicines (except potassium-sparing) increase the risk of hypokalemia.

Special instructions:
Apply only short courses on small areas of the skin.It is recommended to wear loose clothes during treatment.
The drug should not be applied to the face. Avoid contact with eyes. With the development of local infectious complications used in combination with antimicrobial drugs.
Effect on the ability to drive transp. cf. and fur:Does not affect
Form release / dosage:
Ointment for external use 0,025%.

Packaging:For 10 g in an aluminum tube. Each tube together with instructions for use in a pack of cardboard.
Storage conditions:
At a temperature not higher than 15 ° С.
Keep out of the reach of children.

Shelf life:
5 years. Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe
Registration number:LS-001840
Date of registration:01.06.2011
The owner of the registration certificate:AKRIKHIN HFK, JSC AKRIKHIN HFK, JSC Russia
Manufacturer: & nbsp
Information update date: & nbsp20.10.2015
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