Synthomycin Liniment (Synthomycin liniment)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspliniment
Composition:Per 100 g of liniment:

Active substance:


Chloramphenicol [D, L] (synthomycin)

10.00 g

Excipients:


Sorbic acid

0.20 g

Castor oil

20.25 g

Emulsifier №1

8.00 g

Carmellose sodium

1.00 g

Purified water

60.55 g,
Description:Liniment of white or white with a yellowish tint of color, with a weak characteristic odor
Pharmacotherapeutic group:antibiotic
ATX: & nbsp
  • Antibiotics
    • Pharmacodynamics:

    A bacteriostatic broad-spectrum antibiotic, the left- and right-handed isomer of chloramphenicol. Disrupts the process of protein synthesis in a microbial cell (having good lipophilicity, penetrates through the bacterial cell membrane and reversibly binds to the subunit 50S bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to a violation of protein synthesis).

    It is active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, sulfonamides; promotes the purification and healing of burn purulent wounds and trophic ulcers, accelerates epithelization.

    Indications:Infected wounds in phase II wound process (absence of pus, necrotic tissues), caused by sensitive microorganisms, including burns of 2-3 degrees, long-term non-healing trophic ulcers.
    Contraindications:Hypersensitivity to chloramphenicol and other components of the drug, neonatal period (up to 4 weeks), oppression of bone marrow hematopoiesis, acute intermittent porphyria, deficiency of gluco-6-phosphate dehydrogenase, hepatic, renal failure, skin diseases (fungal diseases, psoriasis, eczema).
    In view of the absence of osmotic activity (base - oil, emulsifier), it is not recommended to apply in the first phase of the wound process (copious gnotechenie, pronounced swelling of the tissues, pain and the presence of necrotic tissues).
    Carefully:The period of pregnancy, lactation and early childhood, patients who received previous treatment with cytostatic drugs or radiation therapy
    Pregnancy and lactation:

    Adverse effects during external application to the fetus during pregnancy and breastfeeding have not been identified.

    Dosing and Administration:

    Outwardly.

    After surgical treatment of wounds and burns Synthomycin liniment is applied directly to the wound surface, after which a sterile bandage is applied (or on the dressing, and then on the wound).Tampons with liniment loosely fill the cavities of purulent wounds after their surgical treatment, and gauze turundas with the preparation of Synthomycin liniment are injected into the fistulous passages.

    In the treatment of wounds and burns in the II phase of the wound process - 1 time in 1-3 days, depending on the dynamics of wound healing.

    Side effects:

    To classify undesirable consequences from the point of view of frequency, the following classification is used: very often - 1/10, often - from 1/100 to 1/10, infrequently - from 1/1000 to 1/100, rarely - from 1/10000 to 1 / 1000, very rarely - <1/10000.

    Allergic reactions: skin rash, angioedema.

    From the hematopoiesis: rarely - reticulocytopenia, thrombocytopenia, erythropenia, aplastic anemia, granulocytosis, leukopenia, granulocytopenia.

    Overdose:No cases of overdose of Synthomycin Liniment have been reported to date.
    Interaction:

    With simultaneous use with erythromycin, clindamycin, lincomycin, there is a mutual weakening of the effect due to the fact that chloramphenicol can displace these drugs from the bound state or interfere with their binding to the subunit 50S bacterial ribosomes.

    Reduces the antibacterial effect of penicillins and cephalosporins.

    Special instructions:

    Information on the dependence of the effect of the drug for external use on age is absent.

    Effect on the ability to drive transp. cf. and fur:Information on the adverse effect on the ability to drive vehicles and work with mechanisms is not registered
    Form release / dosage: Liniment, 10%.
    Packaging:

    To 25 g in cans of glass with lids pullable or in tuba aluminum with buds.

    Each tube or jar, together with the instruction for use, is placed in a pack of cardboard.

    Storage conditions:

    In a dry, dark place at a temperature of no higher than 15 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the time specified on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-001419
    Date of registration:11.01.2012
    The owner of the registration certificate:ALTAYVITAMINS, CJSC ALTAYVITAMINS, CJSC Russia
    Manufacturer: & nbsp
    Representation: & nbspALTAYVITAMINS, CJSCALTAYVITAMINS, CJSC
    Information update date: & nbsp13.03.2016
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