Similar drugsTo uncover Dosage form: & nbspSpray nasal dosed with 25 mcg / dose. Composition:Active substance:Stemokin®(L-isoleucyl-L-glutamyl-L-tryptophan sodium salt) in terms of dry matter-0.25 mg Excipients:Sodium chloride 9.0 mg Sodium hydroxide solution 1 M to pH 6.0 to 7.5 Benzalkonium chloride - 0.1 mg Water purified to 1.0 ml Pharmacotherapeutic group:Immunomodulator. ATX: & nbspOther immunostimulants Pharmacodynamics:Stemokin® is the sodium salt of a synthetic peptide consisting of L-amino acid residues of isoleucine, glutamic acid and tryptophan.Stimokin® has an immunomodulatory effect, increases resistance of the organism to local and generalized infections, causes normalization of the changed immunological parameters (relative and absolute number of lymphocytes, CD3+, CD8+, CD19+, CD16+ lymphocytes, the absorptive capacity of monocytes in relation to St. aureus) and an increase in the rates of spontaneous chemiluminescence and affinity for the total antigenic determinant of antibodies, the amount of HLA-DR + lymphocytes. The maximum tropicity of the drug is revealed to the bone marrow.The mechanism of action of Stemokin® is based on the direct effect of the drug on the process of proliferation and differentiation of early hematopoiesis precursors,regulatory influence on the reaction of cellular and humoral immunity and nonspecific resistance of the organism. The drug affects the processes of differentiation of lymphoid cells, inducing the expression of differentiation antigens on leukocytes. After exposure to radiation, the use of cytotoxic drugs, Stemokin® accelerates the recovery of the population of commited and pluripotent hematopoietic progenitor cells. Along with the immunomodulating action, Stemokin® has a pronounced detoxification activity, which is determined by the structure and molecular nature of the drug. The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergic, mutagenic, embryotoxic, teratogenic and carcinogenic effects. Pharmacokinetics:With intranasal administration, the drug is rapidly absorbed, the maximum concentration (Cmax) in the blood is reached after 10-15 minutes. In the bone marrow, liver, kidneys, lymph nodes, Stach is observed 30-40 minutes after administration.The half-life of the drug is 24 hours, completely eliminated from the body within 72 hours of administration.Metabolites of the drug are excreted mainly with urine - up to 60%, up to 20% - with feces. Indications:Stemokin® is used to treat and prevent chronic recurrent furunculosis in adults. Contraindications:- hypersensitivity to the components of the drug;- Pregnancy. Pregnancy and lactation:Women in the period of breastfeeding Stemokin ® should be prescribed only if the expected benefit exceeds the possible risk to the child. Dosing and Administration:Stemokin® is prescribed for 1 to 2 doses in each nasal passage 1 to 2 times a day for 7-10 days.If necessary, the dose and duration of the drug may be increased. Side effects:In rare cases, allergic reactions are possible. Overdose:Data on overdose are absent. Interaction:Data on interactions with other drugs are not available. Special instructions:Features of medical use by children, adults with chronic diseases.Stemokin® is not recommended for children under 18 years of age and adults with chronic liver and kidney disease due to the lack of currently sufficient data on efficacy and safetyapplication of the drug in these patient groups. Effect on the ability to drive transp. cf. and fur:The drug does not affect the coordination of movement, however, during the period of application of the drug, care should be taken when carrying out potentially dangerous activities requiring special attention and quick reactions (vehicle management, working with moving mechanisms, dispatcher and operator work). Form release / dosage:Spray nasal dosed with 25 mcg / dose. Packaging:To 3, 5 or 10 ml in glass bottles. The vials are sealed with aluminum caps or plastic caps equipped with a dispensing pump with a plastic casing, an injector and a protective cap. Each label is labeled with writing paper or label paper, or self-adhesive. For 1 bottle together with instructions for use in a pack of cardboard box. Storage conditions:Store in a dark place at a temperature of no higher than + 25 ° C. Keep out of the reach of children. Shelf life:3 years.Do not use after the expiry date printed on the package. Terms of leave from pharmacies:On prescription Registration number:LSR-003015/09 Date of registration:16.04.2009 / 12.05.2015 The owner of the registration certificate:FARMA BIO LLC FARMA BIO LLC Russia Manufacturer: & nbspMBNPK CITOMED, CJSC Russia Information update date: & nbsp2016-02-15 Illustrated instructions × Illustrated instructions Instructions