Stemokin® (Stemokine®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspSolution for intramuscular injection
Composition:Active substance:
Stemokin®
(L-isoleucyl-E-glutamyl-L-tryptophan sodium salt) * 0.1 mg Excipients:
Sodium chloride 9.0 mg Sodium hydroxide solution 1 M to pH 6.0-7.5 Water for injection up to 1.0 ml
* the amount of active substance is given in terms of dry matter
Description:Colorless transparent liquid. A characteristic odor is allowed.
Pharmacotherapeutic group:Immunomodulator.
ATX: & nbsp
  • Other immunostimulants
    • Pharmacodynamics:Stemokin® is the sodium salt of a synthetic peptide consisting of L-amino acid residues of isoleucine, glutamic acid and tryptophan.
    Stimokin® has an immunomodulatory effect, increases resistance of the organism to local and generalized infections, causes normalization of the changed immunological parameters (relative and absolute number of lymphocytes, CD3+, CD8+, CD19+, CD16+ lymphocytes, and the absorption capacity of monocytes. relation to St. aureus) and an increase in the rates of spontaneous chemiluminescence and affinity for the total antigenic determinant of antibodies, the amount of HLA-DR + lymphocytes. The maximum tropicity of the drug is revealed to the bone marrow.
    The mechanism of action of Stemokin® is based on the direct effect of the drug on the process of proliferation and differentiation of early cells, the precursors of hemopoiesis,regulatory influence on the reaction of cellular and humoral immunity and nonspecific resistance of the organism. The drug affects the processes of differentiation of lymphoid cells, inducing the expression of differentiation antigens on leukocytes. After exposure to radiation, the use of cytotoxic drugs, Stemokin® accelerates the recovery of the population of commited and pluripotent hematopoietic progenitor cells. Along with the immunomodulating effect, it has a pronounced detoxification activity, which is determined by the structure and molecular nature of the preparation. The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.
    Pharmacokinetics:When parenteral administration of the drug, the maximum concentration (Cmax ) in the blood is reached after 5 minutes; in the bone marrow, liver, kidneys, lymph nodes Cmax observed after 30 - 40 minutes after administration.
    The half-life of the drug is 24 hours, completely eliminated from the body within 72 hours of administration.. Metabolites of the drug are excreted mainly with urine - up to 60%, up to 20% - with feces.
    Indications:Stemokin® is used to treat and prevent chronic recurrent furunculosis in adults.
    Contraindications:- hypersensitivity to the components of the drug;
    - Pregnancy.
    Pregnancy and lactation:Women in the period of breastfeeding Stemokin ® should be prescribed only if the expected benefit exceeds the possible risk to the child.
    Dosing and Administration:Stemokin® in the treatment of patients with chronic recurrent furunculosis is prescribed to adults intramuscularly for 1 to 2 ml of solution daily for 10 days. If necessary, the dose and duration of the drug may be increased.
    In the remission phase, the drug is administered intramuscularly daily for 1 ml of the solution for 5-7 days.
    Side effects:In rare cases, allergic reactions are possible.
    Overdose:Data on overdose are absent.
    Interaction:Data on interactions with other drugs are not available.
    Special instructions:Features of medical use by children, adults with chronic diseases.
    It is not recommended to use Stemokin for children and adults with chronic liver and kidney disease due to the lack of safety data on the use of the drug in these patient groups.
    Effect on the ability to drive transp. cf. and fur:The drug does not affect the coordination of movement, however, during the period of application of the drug, care should be taken when carrying out potentially dangerous activities requiring special attention and quick reactions (vehicle management, working with moving mechanisms, dispatcher and operator work).
    Form release / dosage:Solution for intramuscular injection 0.1 mg / ml.
    Packaging:1 ml per ampoule of neutral glass. 5 ampoules per contour pack of PVC film. One or two contour squares, together with instructions for medical use and a knife ampoule or scarifier ampullum, are placed in a pack of cardboard.
    When packaging ampoules with a ring or break point, the ampoule or ampoule ampoule knives are not inserted.
    Storage conditions:Store in a dark place at a temperature of no higher than + 25 ° C. Keep out of the reach of children.
    Shelf life:3 years.
    Do not use after the expiry date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-003014/09
    Date of registration:16.04.2009 / 12.05.2015
    The owner of the registration certificate:FARMA BIO LLC FARMA BIO LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp2016-02-15
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