Stemokin® (Stemokine®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspThe drops are nasal.
Composition:Active substance:
Stemokina®
(L-isoleucyl-L-glutamyl-L-tryptophan sodium salt), calculated on a dry matter, 0.1 mg
Excipients:
Sodium chloride 9.0 mg
Sodium hydroxide 1 M solution to pH 6.0 to 7.5
Water for injection - up to 1.0 ml
Description:Colorless transparent liquid. A characteristic odor is allowed.
Pharmacotherapeutic group:Immunomodulator.
ATX: & nbsp
  • Other immunostimulants
    • Pharmacodynamics:Stemokin® is the sodium salt of a synthetic peptide consisting of L-amino acid residues of isoleucine, glutamic acid and tryptophan.
    Stimokin® has an immunomodulatory effect, increases resistance of the organism to local and generalized infections, causes normalization of the changed immunological parameters (relative and absolute number of lymphocytes, CD3+, CD8+, CD19+, CD16+ lymphocytes, the absorptive capacity of monocytes in relation to St. aureus) and an increase in the rates of spontaneous chemiluminescence and affinity for the total antigenic determinant of antibodies, the amount of HLA-DR + lymphocytes. The maximum tropicity of the drug is revealed to the bone marrow.
    The mechanism of action of Stemokin® is based on the direct effect of the drug on the process of proliferation and differentiation of early hematopoiesis precursor cells, the regulatory effect on the responses of cellular and humoral immunity, and the nonspecific resistance of the organism.The drug affects the processes of differentiation of lymphoid cells, inducing the expression of differentiation antigens on leukocytes. After exposure to radiation, the use of cytotoxic drugs, Stemokin® accelerates the recovery of the population of commited and pluripotent hematopoietic progenitor cells. Along with the immunomodulating action, Stemokin® has a pronounced detoxification activity, which is determined by the structure and molecular nature of the drug. The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.
    Pharmacokinetics:With intranasal administration, the drug is rapidly absorbed, the maximum concentration (Cmax) in the blood is reached after 10-15 minutes. In the bone marrow, liver, kidneys, lymph nodes, Stach is observed 30-40 minutes after administration.
    The half-life of the drug is 24 hours, completely eliminated from the body within 72 hours of administration. Metabolites of the drug are excreted mainly with urine - up to 60%, up to 20% - with feces.
    Indications:Stemokin®, is used to treat and prevent chronic recurrent furunculosis in adults.
    The use of the drug in children has not been studied.
    Contraindications:- hypersensitivity to the components of the drug;
    - Pregnancy.
    Pregnancy and lactation:Women in the period of breastfeeding Stemokin ® should be prescribed only if the expected benefit exceeds the possible risk to the child.
    Dosing and Administration:Stemokin® - drops are prescribed to adults 0.5-1.0 ml in each nasal passage 1-2 times a day for 7-10 days.
    If necessary, the dose and duration of the drug may be increased.
    Side effects:In rare cases, allergic reactions are possible.
    Overdose:Data on overdose are absent.
    Interaction:Data on interactions with other drugs are not available.
    Form release / dosage:Nasal drops of 0.1 mg / ml.
    Packaging:5 ml per bottle of neutral glass. The vials are sealed with rubber stoppers and rolled with aluminum caps. 1 bottle complete with a stopper - pipette or lid - dropper and instructions for medical use in a pack of cardboard box.
    Storage conditions:Store in a dark place at a temperature of no higher than + 25 ° C. Keep out of the reach of children.
    Shelf life:3 years.
    Do not use after the expiry date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-003016/09
    Date of registration:16.04.2009 / 11.12.2015
    The owner of the registration certificate:FARMA BIO LLC FARMA BIO LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp2016-02-14
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