Sugene Avexima (Sulgin Aveksima)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceSulfaguanidineSulfaguanidine
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  • Sugene Avexima
    pills inwards 
    IRBITSK HFZ, OJSC     Russia
    • Dosage form: & nbspPills.
    Composition:
    Active substance: sulfaguanidine monohydrate (sulgine) - 500 mg.
    Auxiliary substances: potato starch - 96 mg, calcium stearate - 4 mg.
    Description:Tablets of white color, flat-cylindrical with a facet and a risk.
    Pharmacotherapeutic group:Antimicrobial agent - sulfonamide.
    ATX: & nbsp

    A.07.A.B   Sulfonamides

    Pharmacodynamics:Antimicrobial bacteriostatic agent. The mechanism of action is due to antagonism with paraaminobenzoic acid (PABA) and competitive inhibition of dihydropteroate synthetase, which leads to a disruption in the synthesis of tetrahydrofolic acid necessary for the synthesis of purines and pyrimidines. Inhibits the growth of E. coli and reduces the synthesis of thiamine, riboflavin, nicotinic acid in the intestine. Sulgin has a bacteriostatic effect on Streptococcus spp., Staphylococcus spp., Escherichia coli, Shigella dysentenae, Proteus vulgaris.
    Pharmacokinetics:After ingestion, the drug is slightly absorbed from the digestive tract, resulting in a high bacteriostatic concentration in the intestine.
    Indications:
    bacterial dysentery;
    colitis and enterocolitis;
    preparation for surgery on the large intestine.
    Contraindications:Hypersensitivity to the components of the drug or other sulfonamides, deficiency of glucose-6-phosphate dehydrogenase, nephrourolythiasis, porphyria, B12-deficiency anemia, pregnancy, lactation, children under 3 years, hyperbilirubinemia (in children).
    Dosing and Administration:In acute dysentery, 2 courses of treatment are performed. The first course: on days 1 and 2, 1 g every 4 hours (6 g / day in total), 3 and 4 days - 1 g every 6 hours (4 g / day), 5 and 6 days - 1 g every 8 hours 3 g / day). If necessary, after 5-6 days, the second course is carried out: 1 and 2 days - 1 g every 4 hours, at night - 8 hours (only 5 g / day), 3 and 4 days - 1 g after 4 hours (4 g / day), at night do not give, 5 day - 3 g / day.
    Children older than 3 years - 0.5 g 4 times a day for 7 days.
    When treating other infections: adults - inside, 1-2 g every 4-6 hours; in the next 2-3 days - half the dose.
    Children older than 3 years - on the first day to 0.1 g / kg / day in equal doses every 4 hours, in the following days - to 0.25-0.5 g every 6-8 hours.
    To prevent postoperative complications from the intestine - to 0.05 g / kg every 8 hours, for 5 days before and 7 days after surgery. Higher doses for adults: single dose - 2 g, daily - 7 g.
    Side effects:
    From the digestive system: nausea, vomiting.
    From the urinary system: crystalluria.
    Allergic reactions: urticaria, exfoliative dermatitis.
    Other: hypovitaminosis B, leukopenia, neuritis.
    Overdose:No overdose information.
    Interaction:
    Reduces the reliability of oral contraception.
    Benzocaine, procaine reduce antimicrobial activity (hydrolysis releases PABA).
    Non-steroidal anti-inflammatory drugs, hypoglycemic drugs (sulfonylurea derivatives), phenytoin and anticoagulants of indirect action increase the severity of the side effects of the drug.
    Ascorbic acid, hexamethylenetetramine increases the risk of developing crystalluria. Myelotoxic drugs increase the manifestation of hematotoxicity of the drug.
    Special instructions:
    In order to prevent crystalluria during the period of treatment, patients should receive a copious drink (2-3 liters / day).
    Early cessation of treatment or inadequate doses can lead to the emergence of resistant strains of pathogens.
    During the period of treatment, the intake of B vitamins is recommended.
    Form release / dosage:
    Tablets 500 mg.

    Packaging:
    For 10 tablets in a contiguous, non-jellied package or a contiguous cell package.
    For 1, 2, 3, 4 or 5 contour cell packs with instructions for medical use are placed in a pack of cardboard. Contour non-cellular packages with an equal number of instructions for medical use or a pack of cardboard are placed in a group package.
    Storage conditions:
    In a dry place, at a temperature not exceeding 30 ° C.
    Keep out of the reach of children.
    Shelf life:
    4 years.
    After expiration date the drug should not be used.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-000845/10
    Date of registration:09.02.2010
    The owner of the registration certificate:IRBITSK HFZ, OJSC IRBITSK HFZ, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp27.08.2015
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