The incidence of adverse reactions listed below was determined as follows:
very often - more than 1/10
often from more than 1/100 to less than 1/10
sometimes from more than 1/1000 to less than 1/100,
rarely from more than 1/10000 to less than 1/1000,
very rarely - from less than 1/10000, including individual cases.
From the nervous system: often - dizziness, drowsiness, sensitivity disorders, including paresthesia and decreased sensitivity.
From the side of the cardiovascular system: often - a transient increase in blood pressure (observed soon after taking the drug), "hot flashes".
From the respiratory system and chest organs: often - dyspnea; light, transient irritation of the mucosa or burning sensation in the nasal cavity or throat, nosebleeds.
From the gastrointestinal tract: often - nausea, vomiting.
From the side of the musculoskeletal system and connective tissue: often a feeling of heaviness (usually transient, can be intense and occur in any part of the body, including the chest and throat).
General and local reactions: often - painful sensations, a feeling of cold or heat, feeling. pressure or contraction (usually transient, can be intense and occur in any part of the body, including the thoracic, cage and throat). Often - weakness, fatigue (usually mild or moderately expressed, transient).
Laboratory indicators: very rarely minor deviations in liver function tests.
Postmarketing surveillance
From the immune system: very rarely - hypersensitivity reactions, including skin manifestations, as well as anaphylaxis.
From the nervous system: very rarely convulsive seizures (in a number of cases, observed in patients with seizures in the anamnesis or with concomitant conditions predisposing to the onset of seizures, some patients did not have risk factors), tremor, dystonia, nystagmus, scotoma.
On the part of the organs of vision: very rarely - flickering, diplopia, decreased visual acuity, blindness (usually transient). However, vision disorders can be caused by the actual migraine attack.
From the cardiovascular system: very rarely - bradycardia, tachycardia, flutter, arrhythmias, transient changes in the ECG, coronary vasospasm, angina pectoris, myocardial infarction. Very rarely, hypotension, Raynaud's syndrome.
From the gastrointestinal tract: very rarely - ischemic colitis, dysphagia, - a feeling of discomfort in the abdomen.