Tiapride (Tiapride)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceTiaprideTiapride
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  • Tiapride
    pills inwards 
    ORGANICS, JSC     Russia
  • Tiapride
    solution w / m in / in 
    ORGANICS, JSC     Russia
  • Tiapridal®
    pills inwards 
    Sanofi-Aventis France     France
  • Tiapridal®
    solution w / m in / in 
    Sanofi-Aventis France     France
    • Dosage form: & nbspsolution for intravenous and intramuscular administration
    Composition:
    In 1 ml of the drug solution is contained as an active substance: tiaprida hydrochloride (in terms of tiaprid) 50 mg; auxiliary substances: sodium chloride - 2, 5 mg, water for injection - up to 1ml.

    Description:
    Transparent colorless or slightly colored liquid.

    Pharmacotherapeutic group:antipsychotic agent (antipsychotic)
    ATX: & nbsp

    N.05.A.L.03   Tiapride

    Pharmacodynamics:
    Pharmacodynamics
    Antipsychotic agent (antipsychotic); has a hypnotic, sedative, analgesic effect. Eliminates dyskinesia of central origin. Has a pronounced analgesic effect, both with interoceptive and exteroceptive pain. The antipsychotic effect is due to the blockade of dopamine B2 receptors of the mesolimbic and mesocortical system. Sedative action is due to blockade of adrenoreceptors of the reticular formation of the brainstem; antiemetic effect.-blockade of dopamine D2-penenTopoB of the trigger zone of the vomiting center; hypothermic action - blockade of hypothalamic dopamine receptors.

    Pharmacokinetics:
    Absorption - fast (in the elderly is slowed down), decreases after eating; bioavailability - 75% (the appointment immediately before meals increases the bioavailability by 20%, the maximum concentration in the plasma - by 40%). The time required to reach the maximum concentration (1.3 μg / ml) after intramuscular injection of 200 mg (2.5 μg / ml) is 30 minutes.
    The connection with plasma proteins is low. Quickly (after 1 hour) is distributed to organs and tissues, penetrates through the blood-encephalic barrier and placental barrier, into breast milk (the concentration is 50% of the plasma).
    Metabolised in the liver.
    The half-life is 2.9 hours for women and 3.6 hours for men. It is excreted by the kidneys - 70% unchanged. Clearance - 330 ml / minute. In chronic renal disease
    Insufficiency, the degree of reduction in excretion is correlated with the magnitude of creatinine clearance.

    Indications:
    Hyperkinetic and dyskinetic syndrome (including the use of antipsychotic drugs (neuroleptics), parkinsonism of vascular origin, late dyskinesias): acute and chronic chorea, nervous tic, senile motor instability, tremor; headache (of neurogenic origin),(alcoholism), psychomotor agitation, behavioral disorders in the elderly, alcoholic psychosis, withdrawal syndrome (alcoholism, drug addiction), chronic pain syndrome (including arthralgia, spasmodic pains in the limbs, pain in cancer patients, pain of neurotic origin).

    Contraindications:
    Hypersensitivity, pregnancy (I trimester), lactation period, children's age (up to 7 years), pheochromocytoma, hypertensive crisis, severe renal / hepatic insufficiency.

    Carefully:
    Epilepsy, decompensated diseases of the cardiovascular system, chronic renal failure, Parkinson's disease, advanced age.

    Dosing and Administration:
    Intravenous or intramuscular.
    Unrestrained pains - intravenously or intramuscularly 200-400 mg / day.
    In the delirious (pre-dilerious) state - intramuscularly or intravenously every 4-6 hours in a daily dose of 400-1200 mg (maximum up to 1800 mg).
    When creatinine clearance is less than 20 ml / min, the daily dose is reduced by 2 times, less than 10 ml / min - by 4 times.
    Children aged 7 years and older - intramuscularly or intravenously at 100-150 mg / day.It is possible to increase this dosage to a maximum of 300 mg / day.

    Side effects:
    Drowsiness, increased fatigue, decreased muscle tone, agitation, extrapyramidal symptoms, malignant neuroleptic syndrome, early dyskinesia (spasmodic torticollis, trismus, oculomotor disorders) and late dyskinesia; phenomena of hyperstimulation (increased anxiety or exacerbation of hallucinatory-delusional symptoms in patients with schizophrenia): dermal
    allergic reactions, orthostatic hypotension, weight gain, hyperprolactinemia, decreased potency, gynecomastia, amenorrhea, galactorrhea, frigidity, hyperthermia.

    Overdose:
    Symptoms: marked sedation, extrapyramidal disorders.
    Treatment: withdrawal of the drug, holinoblokatory.

    Interaction:
    Enhances the effect of drugs that depress the central nervous system (narcotic analgesics, barbiturates, antihistamines, benzodiazepines), as well as inhibitors of angiotensin-converting enzyme and other antihypertensive drugs.
    Incompatible with levodopa and ethanol.

    Special instructions:
    During the treatment it is necessary to refrain from taking ethanol and to be careful when driving vehicles and taking other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

    Form release / dosage:
    Solution for intravenous and intramuscular injection 50 mg / ml.
    10 ampoules of 2 ml together with the instruction for use, with a knife ampoule or scarifier ampoule placed in a box of cardboard.
    5 ampoules of 2 ml each are packaged in a contour mesh package. 2 contour spiral contour packs together with a ampoule or ampoule ampoule knife and instructions for use are placed in a pack of cardboard.

    Packaging:

    10 ampoules of 2 ml together with the instruction for use, with a knife ampoule or scarifier ampoule placed in a box of cardboard.
    5 ampoules of 2 ml each are packaged in a contour mesh package. 2 contour spiral contour packs together with a ampoule or ampoule ampoule knife and instructions for use are placed in a pack of cardboard.

    Storage conditions:
    In the dark place at a temperature of no higher than 30 ° C.
    Keep out of the reach of children.

    Shelf life:
    5 years.Do not use the product after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-007835/08
    Date of registration:06.10.2008
    The owner of the registration certificate:ORGANICS, JSC ORGANICS, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp28.08.2015
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