Included in the formulation
АТХ:M.01.A.E.11 Tiaprofenic acid
Pharmacodynamics:Non-selective reversible cyclooxygenase inhibitor, an enzyme that catalyzes the reaction of the conversion of arachidonic acid to prostaglandin H2, which is the precursor of the remaining prostaglandins, thromboxane A2 and prostacyclin. Has anti-inflammatory and analgesic, as well as antipyretic effect.
Pharmacokinetics:After oral administration, an empty stomach is absorbed up to 80% in the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 1 hour. The connection with plasma proteins is 98%.
Metabolism in the liver.
The elimination half-life is 2 hours. Elimination by the kidneys is 65% and with feces - 35%. Do not cumulate.
Indications:It is used for the treatment of osteoarthritis, rheumatoid arthritis, osteoarthritis, bursitis, tendinitis, pain syndromes of various etiology, including in the postoperative period.
XIII.M05-M14.M05 Seropositive rheumatoid arthritis
XIII.M05-M14.M06.2 Rheumatoid bursitis
Contraindications:Peptic ulcer of stomach and duodenum, ulcerative colitis, gastritis.
Individual intolerance.
Carefully:Severe renal and hepatic insufficiency.
Pregnancy and lactation:Recommendations for FDA - in the first and second trimesters - B, in the third - D. Contraindicated in pregnancy and lactation.
Dosing and Administration:Inside after eating 300 mg 2 times / day.
The highest daily dose: 600 mg.
The highest single dose: 300 mg.
Side effects:Central and peripheral nervous system: dizziness, drowsiness.
The system of hematopoiesis: rarely - thrombocytopenia.
Digestive system: nausea, heartburn, diarrhea.
Urinary system: rarely - oliguria.
Allergic reactions.
Overdose:Pain in epigastrium, nausea, vomiting, drowsiness. Rarely - gastrointestinal bleeding, muscle twitching, respiratory depression, coma.
Symptomatic therapy.
Interaction:Increases the effectiveness of oral hemocoagulants.
With simultaneous use with barbiturates, narcotic analgesics, caffeine, phenothiazine derivatives, diphenhydramine, phenacetin, analgesic effects are enhanced.
Anti-inflammatory effect increases salicylates and metamizol sodium.
Special instructions:Coagulogram monitoring with prolonged use of the drug. During treatment with the drug should refrain from driving the car and works,requiring increased concentration of attention.