Vaccination is carried out 2 times with an interval of 25-35 days in a dose:
1 vaccination - 0.5 ml;
2 vaccination 1.0 ml;
revaccination spend in 2 years in a dose of 1.0 ml.
The drug is injected with a syringe subcutaneously into the subscapular area.
Immediately before inoculation into a vial with typhoid vaccine atwear 5 ml of solvent - sodium chloride isotonic solution for injection 0.9%. The contents of the ampoule are mixed by gentle shaking. The dissolution time should not exceed 1 min.Dissolved drug should be a uniform suspension of light gray color without flakes and foreign inclusions.
A resuspended vaccine that is stored in compliance with asepsis rules can be used within 2 hours.
Opening of ampoules and the vaccination procedure are carried out with strict adherence to aseptic and antiseptic rules.
Reaction to administration
After the introduction of the vaccine, general and local reactions may develop.
General reaction appears after 5-6 hours and is expressed by fever, malaise, headache. Its duration, as a rule, does not exceed 48 hours.
Local reaction characterized by the appearance of skin hyperemia, pain, the formation of infiltrate, which disappear after 3-4 days.
Before mass vaccination, the vaccine must be administered to a limited group (40-50) of people subject to vaccination, equivalent in age and health condition to the majority of the vaccinated.
The reaction is taken 24 hours after inoculation.
An increase in temperature to 37.5 ° C inclusive is regarded as a weak reaction, from 37.6 to 38.5 ° C as an average reaction and from 38.6 ° C and higher as a strong one.
Redness without infiltration and infiltration up to 25 mm in diameter is regarded as a weak reaction, an infiltrate with a diameter of 26 to 50 mm inclusive - as an average reaction and an infiltrate with a diameter of more than 50 mm, as well as an infiltrate with the presence of lymphangitis and lymphadenitis as a strong reaction.
Subject to strict adherence to these instructions, a series of vaccines may be used for subsequent vaccinations if strong and medium temperature reactions and strong local reactions were detected after 24 hours in no more than 7%, or if the average temperature and local responses were detected by no more than 12 % of vaccinated. In the latter case, when calculating the percent, the cases of strong temperature and local reactions are also taken into account.
Given the possibility of shock (in the rarest of cases, especially sensitive individuals), it is necessary to ensure medical supervision of the vaccinated for 30 minutes. Places of vaccination should be equipped with anti-shock therapy.