Chronic recurrent dermatoses
Psoriasis
Timodepressin® is administered intramuscularly for 1-2 ml of the solution daily for 7-10 days, then 2 days for a break, and again a 7-10-day cycle of administration. Depending on the clinical situation, you can spend 3 to 5 cycles. Repeated cycles can be carried out up to 5 times.
Intranasal Timodepressin® is prescribed primarily as maintenance therapy and for the prevention of relapse, as well as in the treatment of children. The drug is injected with 1-2 ml of nasal drops into each nasal passage for 10-14 days.
In patients with generalized psoriatic erythroderma Timodepressin® is administered by intramuscular injection of 2 ml of the solution daily for 14 days, then 14 days intranasally with simultaneous addition of glucocorticosteroid hormones at medium doses (40-60 mg prednisolone).
Atopic dermatitis
Timodepressin® is administered intramuscularly by 1-2 ml of the solution daily for 7-14 days, the course of treatment can be prolonged after a 2-day break. The duration of the course and their number is determined by the clinical and morphological features of the disease.
Intranasal preparation is prescribed primarily as maintenance therapy and for the prevention of relapse or in the treatment of children. Children are prescribed 1-2 ml of nasal drops in each nasal passage for 7 days, followed by a 2-day break and a repeated 7-day course.
Eczema
Timodepressin® is injected intramuscularly with 1-2 ml of the solution daily for 10 days, then 2-5 days for a break, and again a 10-day cycle of administration is repeated. Intranasal preparation is prescribed mainly as a supportive therapy and for the prevention of relapse or in the treatment of children. Children are prescribed 1-2 ml of nasal drops in each nasal passage for 10 days, followed by a 2-5 day break and a repeated 10-day course.
T-cell lymphoma of the skin
With this disease, the drug is administered intramuscularly 2 ml of solution daily by three 7-day courses with 5-day intervals against the background of moderate doses of glucocorticosteroids (30-40 mg of prednisolone).
Pemphigus
The drug is used for various types of pemphigus in complex treatment with glucocorticosteroids. Timodepressin® is prescribed intramuscularly for 1 ml of solution daily for 2 weeks in a complex therapy with prednisolone (60-80 mg / day). After 7-10 days after the start of treatment, the daily dose of prednisolone is reduced by 1/3, followed by a gradual decrease in the dose of prednisolone (by 5 mg every 4-5 days). If necessary, maintain a maintenance dose of prednisolone - 5 mg per day.
Rheumatoid arthritis
Timodepressin® is administered intramuscularly to 1-3 ml of the solution daily for 7-14 days, then 2 times a week. The course of treatment is 16 weeks.
Intranasal Timodepressin® is prescribed primarily as maintenance therapy and for the prevention of recurrences of 1-2 ml of nasal drops to each nasal passage for 5-10 days, then 2 times a week.
Application after cytostatic therapy
To reduce the myelotoxic effect of cytostatic therapy, Timodepressin® is administered intramuscularly daily for 5-7 days to 1-2 ml of the solution. The administration of the drug begins 24-48 hours before the first course of cytostatic chemotherapy (1st and 2nd injection). The third administration is performed 12 hours before the start of polychemotherapy. Depending on the duration of the chemotherapy course, the drug continues to be injected daily with 1-2 ml of the solution once a day. The main efficacy index is the number of leukocytes and granulocytes 3 days before the start of the next course of cytostatic therapy. The drug can also be administered intranasally by 1-2 ml of nasal drops into each nasal passage, or fractional by 0.5 ml in each nasal passage 2-3 times a day, starting 24-48 hours before the first course of chemotherapy. Timodepressin® is indicated for use before courses of polychemotherapy with a duration of no more than 2 weeks and breaks not less than 2 weeks. With long, continuous regimens of cytostatic administration, its use is impractical.
With a recurring course of primary and secondary autoimmune cytopenias, Timedepressin® is recommended to use the first 2 courses as injections, then, with a positive effect, it is possible to switch to a course application of the drug intranasally for several months to stabilize the process.
With insufficient effect from the first courses of drug use, it is recommended to increase the daily dose by 2-3 times and to shorten the break between courses up to 7 days. After achieving the effect, it is necessary to carry out supportive course treatment, during which the dose of the drug can be reduced, and the break between the courses to increase.
In severe recurrent course, Timodepressin® is prescribed in combination with cytostatic immunosuppressants, the dose of which decreases by a factor of 2, and when the effect is achieved, cytostatic immunosuppressants are canceled.
Dosing regimen in children's practice:
For children from 2 to 12 years, Timodepressin® is prescribed intramuscularly for 0.5-1 ml of a solution for intramuscular injection or intranasal for 0.5-1 ml of nasal drops per each nasal passage 1 time per day for 7-10 days, then break 2 days and, if necessary, repeat the course.It is possible to hold 1 to 5 courses.
Children over 12 years of age Timedepryn® are prescribed intramuscularly for 1-2 ml of a solution for injection or intranasal for 1-2 ml of nasal drops in each nasal passage 1 time per day for 7-10 days, then break for 2 days, then 1-2 course for 7-10 days.