The frequency of side effects listed below was determined according to the following (classification of the World Health Organization): very often (more than 10%); often (more than 1% and less than 10%); infrequently (more than 0.1% and less than 1%); rarely (more than 0.01% and less than 0.1%); very rarely (less than 0.01%), including individual reports; the frequency is not known (can not be estimated with the help of available data).
On the part of the blood and lymphatic system
Frequency not known - thrombocytopenia, leukopenia, agranulocytosis, aplastic or hemolytic anemia.
From the side of metabolism and nutrition
Infrequently hypercholesterolemia, hypertriglyceridemia.
Frequency not known - a decrease in glucose tolerance (possible manifestation of latent diabetes mellitus).
From the nervous system
Often - dizziness, headache, drowsiness; infrequently - cramps in the muscles of the lower limbs; frequency not known - confusion, fainting, paresthesia in the extremities (sensation of numbness, "crawling crawling" and tingling).
From the side of the organ of vision
Frequency not known - impaired vision.
From the side of the hearing organ and labyrinthine disorders
The frequency is not known? - hearing impairment, ringing in the ears and hearing loss (usually, reversible) usually in patients with renal insufficiency or hypoproteinemia (nephrotic syndrome).
From the side of the cardiovascular system
Infrequently - extrasystole, tachycardia, increased heart rate, redness of the face; frequency not known - excessive arterial hypotension, orthostatic hypotension, collapse, deep vein thrombosis, thromboembolism, hypovolemia.
From the respiratory system
Infrequently - nasal bleeding.
From the digestive system
Often - diarrhea; infrequently - pain in the abdomen, flatulence, polydipsia; frequency not known - dry mouth, nausea, vomiting, loss of appetite, pancreatitis, dyspepsia, intrahepatic cholestasis.
From the side of the kidneys and urinary tract
Often - increased frequency of urination, polyuria, nocturia; infrequently - increased urge to urinate; frequency not known - oliguria, urinary retention (in patients with urinary tract obstruction), interstitial nephritis, hematuria, increased urea and creatinine levels in the blood.
From the genitals
Frequency not known - a violation of potency.
General disorders and disorders at the site of administration
Infrequently - asthenia (exhaustion), thirst, weakness, increased fatigue, hyperactivity, nervousness.
Laboratory indicators
Infrequently - an increase in the number of platelets; frequency unknown - hyperglycemia, hyperuricemia, a decrease in the number of erythrocytes, leukocytes and platelets, a slight increase in the activity of alkaline phosphatase in the blood, an increase in the activity of certain hepatic enzymes (eg, gamma-glutamyltransferase).
From the skin and subcutaneous tissues
Frequency unknown - skin itching, rash, hives, polymorphic erythema, exfoliative dermatitis, purpura, vasculitis, photosensitivity.
From the side of the musculoskeletal system
Frequency not known - Muscular weakness.
From the side of water-electrolyte and acid-base balance
Frequency not known - hyponatremia, hypochloraemia, hypokalemia, hypomagnesemia, hypocalcemia, metabolic alkalosis. Symptoms that indicate the development of violations of the electrolyte and acid-base state can be headache, confusion, convulsions, tetany, muscle weakness, heart rhythm disorders and dyspeptic disorders; hypovolemia and dehydration (more often in elderly patients), which can lead to hemoconcentration with a tendency to develop thrombosis.
If any of the side effects listed in the instruction are aggravated, or you notice any other side effects not listed in the instructions, inform the doctor about it.