The incidence of adverse events developing with topiramate is classified according to the recommendations of the World Health Organization: very often - at least 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%, including individual reports.
Infections: very rarely - nasopharyngitis.
Violations from the blood and lymphatic system: often - anemia; infrequently - leukopenia, lymphadenopathy, thrombocytopenia, in children - eosinophilia; very rarely - neutropenia.
Disorders from the central nervous system (CNS): very often - drowsiness, dizziness, paresthesia, in children - apathy, attention disturbance; often impaired coordination of movements, nystagmus, lethargy, memory impairment (including anemia), impaired concentration, tremor, amnesia, gait disturbance, hypesthesia, perversion of taste sensations, impaired thinking, decreased mental performance, psychomotor disorders, sedation, speech impairment , dysarthria, cognitive disorders, apathy, mental defectiveness; rarely loss of taste sensitivity, hypokinesia, akinesia, decreased sense of smell, aphasia, apraxia, the appearance of an epileptic aura, a burning sensation in the extremities or on the face, cerebellar syndrome, disturbed circadian rhythm of sleep, complex partial seizures, convulsions, postural dizziness, dysesthesia, increased salivation , dysgraphia, dyskinesia, dysphasia, dystonia, sensation of "goosebumps" in the body, tonic-clonic seizures by type "grand mal", hyperaesthesia, hypogeousia, hypokinesia, hyposmia, peripheral neuropathy, parosmia, pre-memory states, repetitive speech, impaired touch, stupor, fainting, lack of reactions to stimuli, in children - psychomotor hyperactivity.
Mental disorders: often - delayed thinking, pronounced speech disorders, confusion, depression, insomnia, aggressive reactions, agitation, irritability, disorientation, emotional lability, erectile dysfunction, in children - behavioral change, learning disabilities (difficulties with reading, writing, counting); infrequent anorgasmia, sexual dysfunction, tearfulness, early waking up in the morning, euphoric mood, apathy, auditory and visual hallucinations, hypomanic states, decreased libido, mania, panic, paranoid states, perseveration of thinking, impaired reading skills, dyspharmia, increased distraction, sleep disorders, suicidal ideation or attempts, tearfulness; very rarely - a sense of despair.
Disorders of the gastrointestinal tract and biliary system: very often - a decrease in appetite, anorexia; often - nausea, diarrhea; infrequently - abdominal pain, constipation, stomach discomfort, dyspepsia, dry mouth, gastritis, gastroesophageal reflux, gingival hemorrhage, heaviness in the stomach, in children - vomiting, bad breath, flatulence, glossodynia, pain in the mouth, violation sensitivity in the oral cavity; infrequently - discomfort in the epigastric region, hypersecretion of the salivary glands, thirst.
Disturbances from the musculoskeletal system and connective tissue: often - myalgia, including in the chest, muscle spasms, muscle cramps, arthralgia; infrequently - pain in the side, muscle fatigue, muscle weakness, stiffness of the muscles; very rarely - swelling of the joints, discomfort in the extremities.
Disorders from the cardiovascular system: infrequent - bradycardia, palpitations, "hot flashes" of blood, orthostatic hypotension, Raynaud's syndrome.
Common violations: very often - fatigue, irritability, weight loss; often - asthenia, anxiety; children - fever; infrequently - edema of the face, allergic reactions, hyperchloremic acidosis, hypokalemia,increased appetite, metabolic acidosis, polydipsia, cold extremities; very rarely - generalized edema, flu-like syndrome, allergic edema, conjunctival edema, weight gain.
Ophthalmic disorders: often - diplopia, impaired vision, dry eyes; infrequent - accommodation disorder, amblyopia, blepharospasm, transient blindness, unilateral blindness, increased lacrimation, mydriasis, nocturnal, blindness, photopsy, presbyopia, scotoma, including ciliary, decreased visual acuity; very rarely - unpleasant sensations in the eyes, angle-closure glaucoma, involuntary movements of the eyeballs, eyelid edema, myopia, maculopathy, conjunctival edema.
Disorders from the side of the ear: often - pain in the ears, ringing in the ears, children - vertigo; infrequently - deafness, including neurosensory and one-sided, discomfort in the ears, hearing loss.
Disturbances from the respiratory system: often - shortness of breath, nosebleeds; infrequently - hoarseness, hoarseness, dyspnoea with physical exertion; congestion of the nose, hypersecretion in the paranasal sinuses, in children - rhinorrhea. Disturbances from the skin and subcutaneous tissues: often - a rash, alopecia, itching, a decrease in the sensitivity of the face; infrequent - no sweating, allergic dermatitis, redness of the skin, skin pigmentation disorder, macular rash, edema of the face, unpleasant skin odor, hives; very rarely - polymorphic erythema, paraorbital edema, Stephen-Johnson syndrome, toxic epidermal necrolysis.
Disorders from the kidneys and urinary tract: often - nephrolithiasis, dysuria, pollakiuria; infrequently - urolithiasis, hematuria, urinary incontinence, frequent urge to urinate, renal colic, kidney pain; very rarely - renal tubular acidosis.
Change in laboratory indicators: infrequently - decrease in the content of hydrocarbonates in the blood, crystallography, leukopenia, hypokalemia (decrease in serum potassium concentration below 3.5 mmol / l).