Traktotsil is administered intravenously immediately after the diagnosis of "premature birth" in three stages:
- First, for 1 minute, 1 vial of 0.9 ml of the drug is administered without dilution (initial dose of 6.75 mg),
- Immediately thereafter, infusion of the drug at a dose of 300 μg / min (injection rate 24 ml / h, dose of atosiban 18 mg / h) is carried out for 3 hours;
- After this, a long (up to 45 hours) infusion of Tractocil at a dose of 100 mcg / min (injection rate 8 ml / h, dose of atosiban 6 mg / h) is carried out.
The total duration of treatment should not exceed 48 hours. The maximum dose of the drug Traktotsil for the entire course should not exceed 330 mg.
If there is a need for repeated use of the drug Traktotsil, also should begin with the 1 stage, followed by the infusion introduction of the drug (steps 2 and 3). Repeated use can begin at any time after the first use of the drug, it can be repeated up to 3 cycles. If the contractile activity of the uterus does not decrease after 3 cycles of therapy with Traktocil, consideration should be given to using another drug.
Instructions for preparing a solution for infusion (stages 2 and 3):
Concentrate is diluted in one of the following solutions:
- 0.9% solution of sodium chloride,
- Ringer's acetate solution,
- 5 % glucose solution.
From a vial containing 100 ml of one of the above dilution solutions, 10 ml are drained. Then, 10 ml (2 bottles) of Tractocil are injected into the vial to give a concentration of 75 mg / 100 ml.
Shelf life of the prepared solution for infusions is 24 hours. Do not use if insoluble particles are visible in the solution or the solution has changed color.