1. Allergic reactions to the previous administration of the drug or its components.
2. Acute infectious and non-infectious diseases, exacerbation chronic diseases, infectious and non-infectious diseases of the central nervous system in the anamnesis. Vaccinations are carried out not earlier than one month from the moment of recovery (remission).
3. Diseases of the blood.
4. Diseases of the endocrine system.
5. Diseases of the circulatory system.
6. Bronchial asthma and other allergic diseases, severe allergic reactions to food, medicinal and other substances.
7. Systemic lupus erythematosus and other connective tissue diseases.
8. Malignant neoplasms.
9. Pregnancy, lactation.