Trihexyphenidyl (Trihexyphenidyl)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceTrihexyphenidylTrihexyphenidyl
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    • Dosage form: & nbspPills.
    Composition:
    Active substance:
    trihexyphenidyl chloride chloride -2.0 mg
    Excipients:
    sucrose (sugar) - 78.4 mg,
    potato starch - 15.8 mg,
    povidone - 0.8 mg,
    (polyvinylpyrrolidone
    low molecular weight
    medical)
    calcium stearate monohydrate -1.0 mg,
    crospovidone 2.0 mg.
    (polyplasdone XL-10)
    Description:
    Tablets are white, round biconvex.
    Pharmacotherapeutic group:Holin block the central.
    ATX: & nbsp

    N.04.A.A.01   Trihexyphenidyl

    Pharmacodynamics:An antiparkinsonian remedy. Has central and peripheral anticholinergic, as well as miorelaksiruyuschee effect. The mechanism of action is based on competition with acetylcholine on the postsynaptic membrane. Reduces tremor, to a lesser extent affects the rigidity and hypokinesia.Has a peripheral M-anticholinergic action: reduces salivation, less sweating and secretion of the sebaceous glands.
    Pharmacokinetics:When administered orally trihexyphenidyl quickly and completely absorbed from the digestive tract. The half-life is 5-10 hours. Trihexyphenidyl has a high lipotropy, passes well through the blood-brain and placental barriers. Excreted in breast milk. Hydrolyzed in tissues under the action of nonspecific esterases. It is excreted by the kidneys: a small amount in unchanged form, and the main part - in the form of metabolites.
    Indications:
    Parkinsonism of various etiologies; motor disorders associated with the lesion of the extrapyramidal system.
    Contraindications:Hypersensitivity to any of the components of the drug, mechanical stenosis of the gastrointestinal tract, megacolon, zakratougolnaya glaucoma, urinary retention, prostatic hyperplasia (with the presence of residual urine), pulmonary edema, dementia, children's age (under 12 years), pregnancy, lactation.
    Carefully:Decompensated diseases of the heart, kidney or liver, tachycardia, tachyarrhythmia,arterial hypertension, psychosis, acute myocardial infarction, advanced age.
    Dosing and Administration:
    Inside, before meals or during meals.
    The initial dose is 0.5-1 mg / day. The dose is increased gradually by 1 - 2 mg every 3 to 5 days.
    The usual maintenance dose is 6 to 10 mg per day, divided into 3 to 4 doses. In severe cases, it may be necessary to increase the dose to 12-16 mg, divided into 3 to 4 doses. The maximum single dose - 10 mg3 daily - 16 mg.
    Side effects:
    From the nervous system: headache, dizziness, irritability, delirium, hallucinations, increased fatigue, decreased concentration, psychosis. Effects due to anticholinergic activity: dryness of the oral mucosa, paresis of accommodation, increased intraocular pressure, constipation, urinary retention (including prostate adenoma), tachycardia, decreased sweating. From the digestive system: nausea, vomiting. Allergic reactions: skin rash.
    Other: purulent parotitis (due to xerostomia), skin hyperemia, decreased muscle
    tonus, it is possible to develop drug dependence.
    Overdose:
    Large doses of trihexyphenidyl cause blockade of postganglionic endings of the parasympathetic nervous system; the poisoning pattern corresponds to atropine poisoning (mydriasis, dryness of the oral mucosa, tachycardia, intestinal and biliary tractions, and body temperature increase). Disturbances from the central nervous system are expressed by the symptoms of mental and motor excitement, coma or paralysis of the respiratory center may develop.
    Treatment of poisoning: there is no specific antidote. First aid: gastric lavage, activated charcoal, symptomatic treatment.
    Interaction:
    When combined with HI-histaminoblockers, phenothiazine derivatives, tricyclic antidepressants, the intensity of peripheral cholinoblocking effects increases, with chlorpromazine - it is possible to reduce its concentration in the plasma.
    Under the influence of reserpine, the antiparkinsonian effect of trihexyphenidyl decreases (depletion of dopamine reserves in the central nervous system, activation of cholinergic neurons).
    Levodopa increases the antiparkinsonian activity of trihexyphenidyl.When used together with levodopa, the dosage of both drugs should be reduced. Usually in this case, enough 3-6 mg of trihexyphenidyl per day, divided into two doses.
    Under the influence of monoamine oxidase inhibitors, the anticholinergic action of anticholinergic agents used in parkinsonism is enhanced.
    With the simultaneous use of trihexyphenidyl, the effect of sublingual nitrates (due to dry mouth) is reduced.
    The depressive effects of alcohol and drugs that affect the central nervous system may be exacerbated when used with trihexyphenidyl.
    Special instructions:
    During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions. Treatment can not be stopped suddenly. If you receive dry mouth, it is advisable to take it before meals, as otherwise you may experience nausea.
    At the end of treatment or in the case of initiating an alternative treatment, the dose of trihexyphenidyl should be reduced gradually.
    Patients over 60 years of age are prescribed with extreme caution because of the sensitivity to the drug, the possibility of memory impairment and thinking. When using large doses of the drug or in the treatment of patients with predisposing factors (atherosclerosis, advanced age, or patients who have previously developed idiosyncrasy for a drug), mental disorders (unnatural mood increase, agitation, increased irritability), vomiting, or nausea may occur . In these cases, it is necessary to stop treatment. In the course of long-term treatment, the severity of side effects due to anticholinergic action decreases. Periodically monitor eye pressure.
    Form release / dosage:
    Tablets 2 mg.
    Packaging:
    10 tablets per contour cell pack. 1, 2, 3, 4 or 5 contour mesh packages together with instructions for use in a pack of cardboard.
    Storage conditions:
    In accordance with the rules for storage of potent substances. In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:5 years.Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-005076/09
    Date of registration:26.06.2009
    The owner of the registration certificate:MOSCOW ENDOCRINE FACTORY, FSUE MOSCOW ENDOCRINE FACTORY, FSUE Russia
    Manufacturer: & nbsp
    Information update date: & nbsp25.09.2015
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