Triovit® Cardio (Triovit® Cardio)

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Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspfilm-coated tablets
Composition:

1 tablet, film-coated, contains:

active substances: Folic acid 0.5 mg *, pyridoxine hydrochloride 15 mg *, cyanocobalamin 0.015 mg **;

Excipients: cellulose ***, corn starch, microcrystalline cellulose, silicon dioxide colloid, anhydrous, magnesium stearate;

sheath: hypromellose, titanium dioxide, E171, yellow quinoline dye, E104, red dye, E129, talc, macrogol-6000.

* - theoretical quantities;

** - theoretical amount, corresponds to 15 mg of a mixture consisting of 0.1% cyanocobalamin (Ph.Eur.) and mannitol (Ph.Eur.);

*** - cellactose is a sprayable dry compound consisting of 75% of alpha-lactose monohydrate and 25% of dry matter of cellulose powder.

Description:

Round, slightly biconcave tablets with beveled edges, covered with a film shell of orange color.

Pharmacotherapeutic group:multivitamin
Pharmacodynamics:

Triovit® cardio contains vitamins of group B: vitamin B6, vitamin B12 and folic acid (vitamin B9).

Pyridoxine (vitamin B6) together with pyridoxamine and pyridoxal is a precursor of pyridoxal-5-phosphate, which is a cofactor of many enzymes.It is necessary for the normal exchange of amino acids containing a sulfur atom or a hydroxyl group. Vitamin B6 takes part in the metabolism of tryptophan. As a coenzyme, it plays an important role in a number of enzymatic reactions necessary for the synthesis of virtually all neurotransmitters.

Cyanocobalamin (vitamin B12) is necessary for the normal functioning of all cells, especially cells of the bone marrow, central nervous system and gastrointestinal tract. It is involved in the metabolism of fats, proteins and carbohydrates. Active coenzymes of vitamin B12, methylcobalamin and 5-deoxyadenosylcobalamin, are indispensable for the growth and development of cells. They are involved in the synthesis and metabolism of purines, pyrimidines, nucleoproteins, and in maintaining normal hematopoiesis.

Folic acid (vitamin B9) itself is not an active substance; in the human body it passes into biologically active tetrahydrofolic acid. This coenzyme is necessary for the biosynthesis of nucleic acids. It ensures the growth and maturation of red blood cells. Folic acid is necessary for the formation and normal functioning of blood cells.

Vitamins B6, AT12 and folic acid (vitamin B9) play an important role in the metabolism of homocysteine ​​as coenzymes. Vitamin B12 and folic acid are necessary for its reverse conversion to methionine, and vitamin B6 participates in its cleavage to cysteine.

If the metabolism of homocysteine ​​is compromised due to enzymatic deficiency or vitamin B deficiency6, AT12 and folic acid (vitamin B9), homocysteine ​​accumulates in the human body. Its high content in the blood can lead to vascular damage.

Indications:Prevention and treatment of vitamin B deficiency6, AT12 and folic acid (vitamin B9).
Contraindications:

Hypersensitivity to active or other components of the drug; megaloblastic anemia, which developed as a result of vitamin B deficiency alone12, for example, with a deficiency of the internal factor (factor Castle - in vegetarians or elderly people); megaloblastic anemia, which developed due only to deficiency of folic acid; children and adolescents under 14; galactosemia, Lappease lactase deficiency or glucose-galactose malabsorption syndrome; period of pregnancy and lactation.

Pregnancy and lactation:

Pregnant and lactating women should not take the drug (safety is not studied).

Dosing and Administration:

Inside, swallow whole, without chewing. Take after eating, squeezed a small amount of liquid.

The recommended daily intake for adults and adolescents over 14 years is 1 tablet 1-2 times a day.

The duration of therapy is from 1 to 3 months; it is recommended to repeat the course of taking the drug 2-3 times a year.

Side effects:

Side-effect is very rare and occurs after discontinuation of the drug.

From the gastrointestinal tract: diarrhea.

From the skin: reactions of hypersensitivity (hives, eczematous rash) and acne in isolated cases.

Overdose:

There are no reports of drug overdose.

With prolonged intake of vitamin B6 in doses exceeding 1 gram per day, peripheral neuropathy, gastrointestinal disturbances and skin reactions may develop. Very high doses of folic acid (vitamin B9) (15 mg per day) can cause gastrointestinal disturbances (nausea, flatulence, bitter taste in the mouth).

Treatment: symptomatic.

Interaction:

Vitamin B6 can weaken the effect of levodopa.

Isoniazid, penicillamine, cycloserine increase the need for vitamin B6.

Antiepileptics, oral contraceptives, antituberculosis drugs and folic acid antagonists (sodium aminopterin, trimethoprim, pyrimethamine and triamterene) can reduce absorption of folic acid.

Special instructions:

When developing hypersensitivity reactions, the drug should be immediately discontinued. Before simultaneous intake of other vitamin or mineral preparations, you should consult your doctor.

Triovit cardio can be taken by people with diabetes, because it does not contain sucrose.

Effect on the ability to drive transp. cf. and fur:

Reports that the drug is able to influence the ability to drive and other mechanical means are absent.

Form release / dosage:Film-coated tablets.
Packaging:

15 tablets per blister.

2 blisters per pack of cardboard along with instructions for use.

Storage conditions:

Store in a dry, dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe
Registration number:LSR-005802/09
Date of registration:17.07.2009
Date of cancellation:2017-09-13
The owner of the registration certificate:KRKA, dd, Novo mesto, AOKRKA, dd, Novo mesto, AO
Manufacturer: & nbsp
KRKA, d.d. Slovenia
Representation: & nbspKRKA KRKA Slovenia
Information update date: & nbsp13.09.2017
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