Trypsin crystal is used intramuscularly, intrapleural, in the form of aerosols and electrophoresis.
Intramuscularly: trypsin adults 0.005-0.01 g -1-2 times a day, children 0.0025 g once a day. For injections, dilute, immediately before use, 0.005 g of trypsin crystal in 1-2 ml of 0.9% sodium chloride solution or 0.5-2% procaine solution. The course of treatment is 6-15 injections.Apply also electrophoresis with trypsin: for one procedure 10 mg of trypsin (dissolved in 15-20 ml of distilled water), injected from the negative pole.
Inhalation: 0,005-0,01 g in 2-3 ml of 0,9 % solution of sodium chloride through an inhaler or through a bronchoscope. After inhalation, rinse mouth with warm water and rinse nose.
Eye drops: 0.2-0.25% solution, which is prepared immediately before use, 3-4 times a day for 1-3 days.
Intrapleural: once a day, 10-20 mg of the drug dissolved in 20-50 ml of 0.9% sodium chloride solution, after the introduction, a frequent change in body position is desirable; On the 2nd day after instillation they release, as a rule, liquefied exudate.
Locally: in the form of powder or solution, on dry or necrotic wounds, compresses are applied (the solution is prepared immediately before use: 50 mg of trypsin is dissolved in 5 ml of sterile water or physiological solution, in the treatment of purulent wounds - in 5 ml of phosphate buffer solution). Three-layer woven cloth of dialdehyde cellulose impregnated with trypsin is applied to the wound (after its treatment) and fixed with a bandage, leaving the wound for no more than 24 hours. Before application, the cloth is moistened with distilled water or with a solution of furacilin. The time for complete cleansing of the wound from necrotic tissues and pus is 24-72 hours.If necessary - apply again.