When taking therapeutic doses of the drug, it is usually well tolerated. The main side effects of clopidogrel are as follows.
Hemostasis: gastrointestinal bleeding, hematoma, hematuria, hemorrhage in the conjunctiva. Very rarely there was intracranial hemorrhage, hemarthrosis, hemoptysis, hematuria, retroperitoneal, intraocular or pulmonary hemorrhage / bleeding.
On the part of the hematopoiesis system: in clinical studies, extremely marked neutropenia, anemia, thrombocytopenia, granulocytopenia, agranulocytosis, and leukopenia were extremely rare.
On the part of the digestive system: sometimes there may be abdominal pain, indigestion (constipation, diarrhea, nausea), gastritis; in rare cases - vomiting, peptic ulcer of the stomach and duodenum; very rarely - colitis, pancreatitis.
From the side of the liver: very rarely - hepatitis, steatosis.
Kidney and urinary system: very rarely - glomerulonephritis, cystitis.
From the cardiovascular system: In rare cases, edema, heart failure, arterial hypertension can be observed.
Skin and allergic reactions: skin rashes and itching. Very rarely there were urticaria, pruritis, eczema, erythematous rash, bullous rash, maculopapular rash, angioedema, anaphylactoid reactions.
From the musculoskeletal system: very rarely - arthralgia, arthritis.
From the respiratory system: very rarely - bronchospasm.
From the nervous system: In rare cases, headache, dizziness, neuralgia, vertigo, hyperesthesia, paresthesia are possible.
From the side of psychiatry: very rarely - irritability, confusion, hallucinations.
Lab tests: very rarely - a change in the activity of hepatic transaminases, an increase in the creatinine of the blood.
Other: very rarely - vasculitis, fever.