Intravenous (drip, jet).
When generalized fibrinolysis is administered in a single dose of 15 mg / kg body weight every 6-8 hours, the rate of administration is 1 ml / min.
With local fibrinolysis, 250-500 mg 2-3 times a day.
In prostatectomy or bladder surgery, 1 g is injected during the operation, then 1 g every 8 hours for 3 days, then go to the inside of the tablet form until the macrohematuria disappears.
With a high risk of bleeding, with a systemic inflammatory reaction at a dose of 10-11 mg / kg for 20-30 minutes before the intervention.
Patients with coagulopathies before the extraction of the tooth are administered at a dose of 10 mg / kg of body weight, after extraction of the tooth, the tablet form of the preparation is ingested. In the case of a violation of the excretory function of the kidneys, correction of the dosing regimen is necessary: at a creatinine concentration of 120-250 μmol / l, 10 mg / kg 2 times a day are administered; at concentrationCreatinine 250-500 μmol / l administered at 10 mg / kg once a day; at a creatinine concentration of more than 500 μmol / L administered at 5 mg / kg once a day.
The way of application and dose in children's practice.
Uterine bleeding pubertal period: depending on the volume of bleeding and the general condition of the patient, inject 0.5-1 g 3-4 times a day from the 1st to the 4th day of menstruation.
Bleeding from the upper sections of the gastrointestinal tract: 10-15 mg / kg body weight of the patient.
Nasal bleeding: 1 g 3 times a day for 10 days after bleeding. Pulmonary bleeding, including in patients with cystic fibrosis: 1 g 3-4 times a day until the complete cessation of hemoptysis.
Tonsillectomy: intravenously before the surgical operation 10-15 mg / kg, and after the operation - inside 1 g 3 times a day for 5 days.
Hereditary angioedema: 1-1.5 g orally 2-3 times a day or intravenously drip 15 mg / kg of body weight under the control of the blood coagulation system. For the prevention and treatment of bleeding during surgery: 10 mg / kg body weight.
Dental procedures: inside 10 mg / kg of body weight after extraction of the tooth, rinsing of the oral cavity with tranexamic acid can also be used. Surgery of congenital heart disease:
1) a loading dose of 10 mg / kg, followed by infusion of the drug at a dose of 1 mg / kg / h;
2) 10 mg / kg of the drug is injected into the circulatory system;
3) The patient receives 10 mg / kg after the administration of protamine.
Spinal surgery, liver transplantation: 20 mg / kg body weight with cutaneous incision followed by infusion of 1 mg / kg / h, 20 mg / kg every 6-8 hours in the postoperative period.
Menorrhagia in women with coagulopathy, including with von Willebrand's disease, deficiency of blood coagulation factors VII, X and XI: 15-20 mg / kg body weight 3-4 times a day with the onset of bleeding before it stops (1-1.5 g 3 times a day). Bleeding from the upper gastrointestinal tract in patients with coagulopathy: 10 mg / kg body weight 3-6 times a day intravenously. With erosive gastritis: 10 mg / kg body weight 3-4 times a day is injected into the nasogastric tube to stop bleeding.
Nasal bleeding in patients with coagulopathies: 15-20 mg / kg or locally (wetted tourniquet).
Dental procedures in patients with coagulopathies: inside 15-20 mg / kg of body weight before the operation and after tooth extraction, then 3 times a day for 8-10 days. You can rinse your mouth for 2 minutes 4 times a day for 2 days.To treat the bleeding that continues after tooth extraction, inject bleeding at a dose of 20 mg / kg intravenously, and after performing local hemostasis, 10 mg / kg orally every 6 hours for several days.
In the formation of labial or gingival hematomas for the implementation of hemostasis is administered at a rate of 7.5-10 mg / kg every 6 hours.
In manipulations requiring a gingival incision or local exposure to bones, it is advisable to use continuous infusion at a dose of 1.5 mg / kg / h. Surgical treatment of patients with hemorrhagic disorders: 10 mg / kg of body weight are administered 3 times a day intravenously immediately before and after the operation. Orally 15-20 mg / kg body weight 3 times a day after surgery, when the patient can take the pill within 7-10 days.
In the endoprosthesis of the knee joint, an additional dose is applied immediately before the removal of the hemostatic tourniquet.
In operations in the lower urinary tract, a dose of 2 g is administered 3 times a day on the day of the operation and on the first day after the operation, along with irrigation of the bladder.
In small operations, the drug can be used only inward 2 hours before the operation and within one week after the operation.