Cefamabol ® is administered intramuscularly or intravenously.
| Clearance | Severe infections | Moderately severe infections |
| creatinine (ml / min) | - | |
| 50-80 | 2 g every 6 hours or 1.5 g every 4 hours | 0.75 - 1.5 g every 6 hours |
| 25-50 | 1.5 g every 6 hours or 2 g every 8 hours | 0.75 - 1.5 g every 8 hours |
| 10-25 | 1 g every 6 hours or 1.25 g every 8 hours | 0.5 - 1 g every 8 hours |
| 2-10 | 0.67 g every 8 hours or 1 g | 0.5-0.75 g each |
| | every 12 hours | 12 hours |
| Less than 2 | 0.5 g every 8 hours or 0.75 g | 0.25-0.5 g every |
| | every 12 hours | 12 hours |
Patients on hemodialysis are given intravenous / intravenous / 1 g every 12 hours (if an intravenous injection is used, then after the completion of the hemodialysis session, 1 / 2-1 / 3 doses are additionally given).
In children older than 1 month. The daily dose is 50-100 mg / kg body weight, which is divided into 3-6 injections at intervals of 4-8 hours. In severe infections, the daily dose can be increased to 150 mg / kg / day, but should not exceed 12 g.
The duration of therapy with Cefamabol® depends on the severity, localization, features of the course of the infectious process, the patient's response to treatment, and is determined individually by the treating physician.The administration of the drug is continued, at least for another 48-72 hours after the normalization of body temperature. When treating infections caused by group A beta-hemolytic streptococci, the duration of therapy should be at least 10 days.
For the prevention of postoperative infectious complications in adults
Cefamabol® is administered iv at a dose of 1 g or 2 g together with premedication or anesthesia, but not earlier than one hour before the operation; then (if necessary) in / in or / m 1 g or 2 g every 6 hours for 24-48 hours after the operation. Children over 3 months. administered in / in the same regimen as in adults, at a rate of 50-100 mg / kg per day with intervals between administrations of 6 hours.
Rules for the preparation of solutions and administration
For intravenous injection of 1 g of dry sterile powder of the drug Cefamabol ® is dissolved in 3 ml of sterile water for injection, 0.9% sodium chloride solution or 0.5% lidocaine solution. Enter deeply intramuscularly into areas of the body with a pronounced muscular layer (upper-outer quadrant of the buttock or lateral surface of the thigh). It is recommended that an aspirate test be performed to avoid the unwanted introduction of the solution into the blood vessel.The use as a solvent of 0.5% lidocaine solution is contraindicated in persons with increased sensitivity to local anesthetics of the amide type (for more information refer to the instructions for use of lidocaine).
For IV injection 1 g of Cefamabol® is dissolved in 10 ml of sterile water for injection, 0.9% sodium chloride solution or 5% dextrose solution. Enter intravenously slowly, for 3-5 minutes; it is possible to administer through a special node or port for injection of a system for intravenous infusions if the patient receives parenterally compatible fluids with Cefamabol.
For IV injection 1 g of Cefamabol® is dissolved in 10 ml of sterile water for injection. The resulting solution is transferred to a vial containing 50-100 ml of a compatible infusion medium. Enter intravenously drip, the duration of administration depends on the volume of the solution and can be 10-30 minutes or more. Cefamabol® solution is compatible with 5% dextrose solution, 0.9% sodium chloride solution, 10% dextrose solution, an aqueous solution containing 0.2% sodium chloride and 5% glucose; aqueous solution,containing 0.45% sodium chloride and 5% glucose; an aqueous solution containing 0.9% sodium chloride and 5% glucose, M / 6 sodium lactate solution.