In / m, in / in struyno (for 3-5 minutes) or drip. The IV route is preferred in patients with bacterial septicemia, parenchymal abscess limited (in particular, intra-abdominal abscess), peritonitis, or other severe or life-threatening infections. The dose of the drug, the way of doing it should be determined depending on the patient's condition, the severity of the infection and the sensitivity of the microorganism.
Usually the dose of the drug in adults is 1-2 g every 8-12 hours.
In uncomplicated urinary tract infections - 500 mg every 12 hours IV or / m. In the treatment of infections caused by P. aeruginosa, the dose should be increased, since many strains P. aeruginosa are moderately sensitive to ceftizoxime. In the event that the response to treatment does not occur within the next time, it is necessary to start another therapy.
For infections of other localizations, 1 g every 8-12 h IV or IM.
Heavy or refractory infections - 1 g every 8 h or 2 g every 8-12 h iv or in / m.If it is necessary to administer 2 g / m dose should be divided and introduced separately into different large muscles.
Infectious-inflammatory diseases of the pelvic organs - 2 g every 8 hours in / in. In the event that the agent is suspected
C. trachomatis, it is necessary to additionally introduce antibiotics effective against
C. trachomatis, because the
ceftizoxime is inactive in relation to this pathogen.
Life-threatening infections - 3-4 g every 8 hours in / in. There is an experience of administering doses up to 2 g every 4 h.
For treatment of uncomplicated gonorrhea -1 g IM once.
With normal kidney function, doses of 2 to 12 g IV may be given daily, with bacterial septicemia IV, doses of 6-12 g are usually administered for several days, after which the dose is gradually reduced in accordance with the clinical response and laboratory parameters .
Children older than 6 months - 50 mg / kg / day every 6-8 hours. If necessary, the dose may be increased to a total daily dose of 200 mg / kg, but should not exceed the maximum recommended dose in adults for the treatment of severe infections.
If the excretory function of the kidneys is disturbed, correction of the dosing regimen is required depending on the values of creatinine clearance (CK).After an initial dose of 500 mg or 1 g IV or IM, a dose reduction should be made according to the data in the table:
| CK ml / min | Less severe infections | Life-threatening infections |
| 50-79 | 500 mg every 8 hours | 750 mg-1.5 g every 8 hours |
| 5-49 | 250-500 mg every 12 hours | 500 mg-1 g every 12 hours |
| 0-4 | 500 mg | 500 mg-1 g every 48 hours |
| (patients on hemodialysis) | every 48 hours or 250 every 24 hours | or 500 mg every 24 hours |
Patients on hemodialysis do not need an additional dose, but the drug should be administered (according to the table above) at the end of the hemodialysis session.
To prepare a solution for intravenous injections, the contents of the vial (1 g) are dissolved in 3 ml of sterile water for injection.
To prepare a solution for IV injections, the contents of the vial (1 g) are dissolved with 10 ml of sterile water for injection. The prepared solution can be injected directly into the vein, or through the cannula for the introduction of parenteral fluids. For intravenous administration, the previously reconstituted solution is then diluted in 50-100 ml of 0.9% sodium chloride solution, 5% or 10% dextrose (glucose) solution, 5% dextrose solution and 0.9%, 0.45% or 0.2% sodium chloride solution, in Ringer's and Ringer's lactate solution, 5% sodium bicarbonate solution.