Included in the formulation
АТХ:G.02.C.X Other drugs for use in gynecology
Pharmacodynamics:Vegetable complex composition with a complex of pharmacological effects.
Cyclobortanic triterpenoids, including Shengmanol, acetylsenschmanol, have hypotensive and sedative effects, increase myocardial contractility, without affecting the heart rate. In combination with saponins and phytosterol, they exhibit lipid-lowering, antioxidant and angioprotective activity.
It has an estrogen-like effect due to binding to the estrogen receptors of hypothalamic neurons (affecting the hypothalamus-pituitary-ovary system). This leads to a decrease in the release of gonadotropin-releasing hormone and the subsequent decrease in LH secretion in the anterior pituitary gland. Reducing the release of gonadotropins leads to the elimination of psychoemotional and vegetovascular disorders,arising in the pre-climacteric and menopausal periods and caused by a sharp decrease in the production of estrogens with a simultaneous increase in the secretion of LH and FSH.
Increases diuresis, increases the secretion of digestive glands, relaxes the smooth muscles of the intestines and urinary tracts, has antipyretic and anti-inflammatory effect.
Pharmacokinetics:Not studied.
Indications:Vegeto-vascular disorders in the period of menopause, pre- and postmenopause (blood flushes to the face, increased sweating, sleep disturbance, increased nervous excitability, mood changes, apathy), neurocirculatory dystonia by hypertonic type, mild arterial hypertension, atherosclerosis prevention, menopausal neurosis, migraine, insomnia, pregnancy toxicity accompanied by hypertension.
V.F40-F48.F45.3 Somatoform dysfunction of the autonomic nervous system
V.F50-F59.F51.2 Sleep and wakefulness disorder inorganic etiology
VI.G40-G47.G43 Migraine
IX.I10-I15.I10 Essential [primary] hypertension
IX.I70-I79.I70 Atherosclerosis
XIV.N80-N98.N95.1 Menopause and menopause in women
XV.O10-O16.O13 Pregnancy-induced hypertension without significant proteinuria
Contraindications:Hypersensitivity, pregnancy, breast-feeding.
Children under 12 years.
Contains salicylates, is contraindicated in persons with hypersensitivity to them.
Lactose intolerance, lactase deficiency, glucose-galactose malabsorption (due to the content of lactose in the preparation);
Carefully:For gastritis with increased secretion, use with caution.
Patients with a history of liver disease should consult with a doctor before taking the drug.
Pregnancy and lactation:Category of recommendations for FDA is not defined. Risk of spontaneous abortion: contraindicated.
There is no information on the penetration into breast milk. Do not apply.
Dosing and Administration:Take inside with a small amount of liquid, at the same time of day (morning or evening), treatment course 1-1,5 months.
Side effects:In rare cases: temporary pain in the stomach, allergic reactions to the components of the drug.
There are isolated reports of toxic effects on the liver in preparations containing tsimitsifugu.
If any of the above or other adverse reactions appear, you should cancel the drug and consult a doctor.
Overdose:Vomiting, headache, dizziness, pain in the extremities, lowering blood pressure. One case of seizures and one case of fulminant hepatitis, requiring liver transplantation, were recorded.
Interaction:Antihypertensive drugs - potentiation of the effect.
Special instructions:Do not use for replacement hormone therapy instead of estrogen because there is no cardioprotective action or protection against osteoporosis.
Without the recommendation of a doctor should not be used simultaneously with estrogen-containing drugs. If there are symptoms suggestive of liver damage (for example, fatigue, loss of appetite, yellowing of the skin and eyes, severe pain in the upper abdomen with nausea and vomiting, dark urine), stop taking the drug and consult a doctor.
Patients who have undergone or are undergoing treatment for hormone-dependent tumors (in particular, the breast) should not use the drug without consulting a doctor.