The incidence of side effects is characterized as very common (> 10%), common (> 1% <10%), unresponsive (> 0.1% <1%), rare (> 0.01% <0.1%) and very rare (<0.01%).
From the nervous system: > 10% - headache, tremor, dizziness, drowsiness insomnia, agitation, nervousness; > 1% <10% - migraine, paresthesia, sleep disturbance, impaired concentration, drowsiness, amnesia, anxiety, decreased libido, increased appetite, anorexia, apathy, suicidal attempts, confusion of thoughts; > 0.01% <0.1% - asthenia, mood changes, aggressive behavior, emotional lability, agitation, mania, hypomania, panic behavior, paranoid reaction, psychosis, excessive fatigue, anxiety, extrapyramidal disorders, convulsions, euphoria, increased libido , serotonin syndrome (agitation, confusion, diarrhea, hyperthermia, hyperreflexia, ataxia, tremor, increased sweating, agitation, uncontrolled behavior); <0.01% - hallucinations, depersonalization, panic attacks.
From the side of the cardiovascular system:> 10% - atrial flutter (heart rhythm disturbance); > 1% <10% - tachycardia; > 0.01% <0.1% - a bradycardia; Orthostatic hypotension, increase or decrease in blood pressure; <0.01% - supraventricular and ventricular arrhythmias.
From the gastrointestinal tract: > 10% - nausea, dry mouth, constipation, diarrhea; > 1% <10% - dyspepsia, vomiting, abdominal pain, flatulence, anorexia, increased salivation; > 0.01% <0.1% - an increase in the activity of liver enzymes.
From the side of the urinary system: > 1% <10% - frequent urination, polyuria. Disturbances of metabolism: > 1% <10% - decrease or increase in body weight.
From the respiratory system: > 1% <10% - rhinitis, sinusitis; > 0.01% <0.1% - cough.
From the side of the reproductive system:> 1% <10% - violations of ejaculation, decreased libido, female anorgasmia, dysmenorrhea, impotence, menstrual irregularities; <0.01% is a galactorrhea.
From the skin: > 10% - increased sweating; > 1% <10% - rash, itching; > 0.01% <0.1% - photosensitivity, epidermal necrolysis; <0.01% - angioedema.
From the side of the organ of vision: > 10% - violation of accommodation; > 1% <10% - visual impairment, <0.01% - mydriasis.
From the sense organs:> 1% <10% - a violation of taste.
From the side of the auditory and vestibular apparatus: > 1% <10% - noise in the ears.
From the side of the musculoskeletal system: > 10% - myalgia; <0.01% - arthralgia.
On the part of the organs of hematopoiesis:> 0.01% <0.1% - bleeding is rarely possible (for example, bleeding due to gynecological causes, gastrointestinal bleeding, ecchymosis), thrombocytopenia.
Other:> 10% - asthenia; > 1% <10% - fatigue; > 0.01% <0.1% - allergic reactions, fainting, malaise, hyperthermia, mastodonia, yawning, gnashing of teeth, dyspnea; hyponatremia; <0.01% anaphylactoid reaction.