Tubosan® (Tubosan®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceMethyldioxotetrahydropyrimidine sulfonisonikotinoyl hydrazideMethyldioxotetrahydropyrimidine sulfonisonikotinoyl hydrazide
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  • Tubosan®
    capsules inwards 
    Biopharm Pravo-Alfa, ZAO     Russia
    • Dosage form: & nbsptoapsules
    Composition:

    Active substance:

    Methyldioxotetrahydropyrimidine sulfonisonikotinoyl hydrazide (crystal) - 0.2 g.

    Excipients: Potato starch - sufficient amount to obtain a capsule weighing 0.205 g.

    Hard gelatine capsules: iron (iron oxide), iron (red iron oxide), titanium dioxide, gelatin.

    Description:Gelatin capsules number 1 of yellow color. The contents of the capsules are white or white with a creamy tinge powder, odorless.
    Pharmacotherapeutic group:Immunostimulating agent
    ATX: & nbsp

    L.03.A.X   Other immunostimulants

    Pharmacodynamics:

    Tubosan ® has an immunomodulatory effect, normalizes the immune status indicators of the body. Stimulates the phagocytic activity of mononuclear cells. The use of Tubosan® leads to an increase in the number of T-helpers with a decrease in the number of T suppressors and normalization of the immunoregulatory index. Stimulates the proliferative activity of B-lymphocytes, the formation of antibody-producers and immunoglobulins.

    Tubosan® is practically non-toxic, does not have allergic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.
    Pharmacokinetics:

    After oral intake absorbed in the gastrointestinal tract, the maximum concentration in the blood is reached after 6 hours, the blood is stored for 12-18 hours. Due to weak solubility, almost 50% of the drug is released through the gastrointestinal tract.

    Indications:

    Tubosan® is indicated for use in adults for:

    - prevention of seasonal rise in the incidence of ARVI;

    - in the complex therapy of diseases accompanied by the development of immune deficiency, including acute and chronic nonspecific respiratory diseases, bacterial prostatitis, chlamydia, tuberculosis and leprosy.

    Contraindications:

    Individual intolerance, pregnancy, lactation, children under 18 years.

    Dosing and Administration:

    Tubosan® is prescribed for adults:

    - with the preventive purpose: for 5-10 days for 200 mg in 12 hours 2 times a day;

    - with ARVI, influenza, parainfluenza and other respiratory infections: on 200 mg 2 times a day with an interval of 12 hours for 2-3 weeks;

    - with chronic nonspecific lung diseases, chlamydia: 200 mg twice a day with an interval of 12 hours for 30 days;

    - with bacterial prostatitis: 200 mg every 8 hours 3 times a day. The course of treatment - 3 weeks, with persistent course of the disease - up to 6 weeks with a decrease in the daily dose to 400 mg;

    - with mycobacteriosis (tuberculosis, leprosy): 200 mg in 8 hours 3 times a day for up to 6 months.

    Single dose 0.2-0.4 g; daily dose of 0.4-1.6 g.

    Tubosan® is taken 30 minutes before meals or 2 hours after meals. Incompatibility of Tubosan® with food was not noted.

    Side effects:

    The drug is well tolerated.

    With individual sensitivity allergic reactions are possible.

    Overdose:Not described.
    Interaction:

    Possible simultaneous use of Tubosan ® with other means of specific and non-specific therapy (antibiotics, anti-tuberculosis drugs, bronchodilators, including β2agonists, glucocorticosteroids, antioxidants, anticoagulants, vasodilators).

    Form release / dosage:Capsules, 200 mg.
    Packaging:

    For 10 pieces in a planar cell pack.

    For 1, 2, 3 contour mesh packages along with the instruction for use are placed in a pack of cardboard box.

    The packets are placed in a group package.

    For hospitals - 400, 600 or 800 contour mesh packages together with an equal number of instructions for use are placed in a group package of cardboard box.

    Storage conditions:

    In dry, the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    4 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-006593/08
    Date of registration:14.08.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:Biopharm Pravo-Alfa, ZAOBiopharm Pravo-Alfa, ZAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp04.01.2017
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