Doses and duration of substitution therapy depend on the severity of the hemostatic function, on the localization and volume of bleeding, and on the clinical condition of the patient.
The calculation of the required dose is based on empirical data:
1 ME coagulation factor IX per kg of body weight increases the activity of coagulation factor IX in plasma by 0.8% and 1 ME Coagulation factor II increases the activity of factor II or X by 1.5%, respectively.
The required dose is determined by the following formula:
Initial dose = body weight (kg) x required increase in factor IX (%) x 1.2
Important: in each individual case, when determining the necessary amount and frequency of the drug, always take into account clinical effectiveness. In the event of bleeding, the activity of the coagulation factor IX in the relevant period should not be lower than the level of activity of the corresponding factor in blood plasma (% of the norm) indicated in the table:
| Severity of bleeding | Required level of coagulation factor IX in blood plasma | Duration of administration |
| Hemorrhages in the joint | 30% | At least one day, depending on the severity of the bleeding. |
| Bleeding in the muscles | 30-50% | 3-4 days or until the bleeding stops. |
| Minor head trauma |
| Extraction of the tooth |
| Intervention of moderate severity |
| Hemorrhages from the oral cavity |
Acquired deficit of phof the prothrombin complex
The dose and duration of substitution therapy depend on the severity of the disorder of the hemostatic function, the localization and severity of bleeding, and the clinical condition.
The dosage regimen also depends on the half-life in vivo necessary factor and body weight of the patient.To ensure complete control of therapy, as far as possible, it is necessary to monitor blood coagulability by means of coagulation tests.
In the case of massive bleeding and before operations that are accompanied by a high risk of bleeding, it is necessary to administer the prothrombin complex preparation to normal prothrombin time.
Cooking method
Uman Complex must be dissolved immediately before administration. Do not use the solution in the presence of flaky and other mechanical inclusions in it.
The drug is administered intravenously for 3-5 minutes under the control of the patient's pulse.
Add the solvent to the lyophilizate through a double needle and rotate the vial with the concentrate until completely dissolved. The lyophilizate can dissolve faster when the solvent is heated in a water bath to a temperature of no higher than 37 ° C. With incomplete dissolution of the drug, it will be difficult to filter the drug through the filter needle. To avoid foaming, the solvent must be slowly poured onto the wall of the vial with lyophilizate. After the preparation of the solution, it must be dialed into the syringe,using the supplied filter needle and injected intravenously with the supplied kit.