Vaccine plague alive - instructions for use, dose, side effects, contraindications

Active substanceVaccine for the prevention of plagueVaccine for the prevention of plague

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Vaccine plague alive

lyophilizate d / inhal. for injections cutaneous

48 CSRI MINISTRY OF THE RUSSIAN FEDERATION Russia

Vaccine plague alive

lyophilizate d / inhal. for injections cutaneous

Stavropol Scientific Research Anti-Plague Institute, FGUZ Russia

Vaccine plague alive

pills inwards

48 CSRI MINISTRY OF THE RUSSIAN FEDERATION Russia

Vaccine plague molecular microencapsulated (HFMM)

lyophilizate PC

State Scientific and Technical Center of Rospotrebnadzor, FBUN Russia

Dosage form: & nbsplozenges

Composition:

Vaccine plague alive, resorption tablets, is a lyophilized live culture of a vaccine strain Yersinia pestis EV line NIIEG (40 billion, live microbial cells in a pill);

stabilizer: dextrin (6 mg per tablet), ascorbic acid (6 mg per tablet), lactose (60 mg per tablet), thiourea (6 mg per tablet);

filler: vanillin (2 mg per tablet), medical glucose (0.44 g in tablet), cocoa powder (11.4 mg per tablet), calcium stearate (12 mg tablet), potato starch (11.4 mg per tablet), menthol (2.2 mg tablet), saccharin (1.1 mg tablet).

Description:

Tablet is light brown in regular round shape with solid edges, flat and flat surface.Has a smell of cocoa, vanillin and menthol.

Pharmacotherapeutic group:MIBP vaccine

ATX: & nbsp

J.07.A.K.01 Plague bacteria whole inactivated

J.07.A.K Vaccine for the prevention of plague

Pharmacodynamics:

The vaccine causes vaccines to develop immunity to a plague lasting up to 1 year.

Indications:

Prevention of plague.

Inoculations are subject to a population from 14 years of age living in enzootic plague areas; persons working with live cultures of the plague pathogen infected with laboratory animals, conducting a study of a material suspected of being infected with a plague pathogen.

Contraindications:

1. Acute infectious and non-infectious diseases, chronic diseases at the stage of exacerbation - vaccinations are given no earlier than 1 month after recovery (remission).

2. Primary and secondary immunodeficiencies. When treated with steroids, antimetabolites, chemo- and roentgenotherapy - vaccinations are given no earlier than 6 month after the end of treatment.

3. Systemic diseases of connective tissue.

4. Malignant neoplasms and malignant blood diseases.

5. Diseases of the endocrine system.

6.Allergic diseases (bronchial asthma, anaphylactic shock, Quincke's edema in the anamnesis).

7. Pregnancy and lactation.

In each individual case for diseases not included in this list, vaccination is carried out only with the permission of the appropriate specialist doctor.

In order to identify contraindications, the doctor (paramedic) on the day of vaccination conducts a survey and examination of the vaccine with mandatory thermometry.

Dosing and Administration:

One inoculation dose is one tablet. Vaccination is carried out once by taking one tablet, which must be actively resorbed or thoroughly chewed for 5-7 minutes. Swallowing the whole tablet is FORBIDDEN!

After taking the pill for 30 minutes, it is not recommended to drink, take food, smoking.

Revaccination carried out after one year (in an unfavorable epidemic situation - after 6 months) with the same dose.

Before the vaccine is used, the integrity of the package, the presence of labels on the cans, the appearance of the tablets are monitored. Unsuitable is the drug in a container with broken integrity, with a changed appearance (tablets with uneven edges, cracks and spots), expired, no labels or missing information on them.

Side effects:

Inoculations with the vaccine can be accompanied by both local and general reactions.

Local Reactions manifested in the form of limited, mild hyperemia of the oral mucosa in the tonsils and minor pain experienced during swallowing. Local reactions occur 1-3 days after vaccination and last for 2-3 days.

General reactions may be mild, moderate and severe and are accompanied by an increase in body temperature, malaise, headache, weakness, pain in the muscles.

Weak reaction - an increase in body temperature to 37.1-37.5 ° C with duration 1-2 days, should be observed no more than in 3% of cases.

Average - increase in body temperature to 37.6-38.5 ° C with a duration of 1-2 days, total loss of ability to work no more than 1 day. The average reaction should be observed in no more than 2% of cases.

Strong - increase in body temperature above 38.5 ° C duration l-3-day, total loss of ability to work more than 1 day. A strong reaction should be observed in no more than 1% of cases.

Overdose:In recommended doses, an overdose is not possible.

Interaction:

Simultaneous oral vaccination of adults against plague and cutaneous versus brucellosis and tularemia in different parts of the outer surface of the upper third of the shoulder is allowed.

The vaccine is sensitive to antibiotics, and therefore immunization against the background of antibiotics is not allowed.

Form release / dosage:Lozenges.

Packaging:

For 40 or 90 tablets in glass jars made of light-protective glass with plastic screw caps, filled with sealant.

One bank in a pack with instructions for use.

Storage conditions:

Store in accordance with SP 3.3.2.1248-03 at a temperature of 0 to 8 ° C, out of reach of children.

Transport in accordance with SP 3.3.2.1248-03 at a temperature of 0 to 8 ° C.

Shelf life:

1 year.

The drug with expired shelf life is not subject to application.

Terms of leave from pharmacies:For hospitals

Registration number:LSR-008997/09

Date of registration:09.11.2009 / 05.11.2014

Expiration Date:Unlimited

The owner of the registration certificate:48 CSRI MINISTRY OF THE RUSSIAN FEDERATION 48 CSRI MINISTRY OF THE RUSSIAN FEDERATION Russia

Manufacturer: & nbsp

48 CSRI MINISTRY OF THE RUSSIAN FEDERATION Russia

Information update date: & nbsp13.01.2017

Illustrated instructions

Instructions

Vaccine plague alive (Vaccinum pestosum vivum)