Vaccine for the treatment of staphylococcal infections (Vaccine for the treatment of staphylococcal infections)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Vaccines, serums, phages and toxoids

Included in the formulation
  • Staphylococcal medicinal vaccine (Staphylococcal antifagin)
    solution PC 
    BIOMED them. I.I.Mechnikova, OJSC     Russia
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    VED

    АТХ:

    J.07.A   Vaccines for the prevention of bacterial infections

    J.07   Vaccines

    Pharmacodynamics:

    The introduction of the drug in accordance with the approved scheme causes in vaccines the formation of a specific antimicrobial anti-staphylococcal immunity.

    Pharmacokinetics:Data on the pharmacokinetics of the drug are not available.
    Indications:

    Treatment of pustular skin diseases of staphylococcal etiology: boils, carbuncles, stafilodermiya.

    ICD-10

    XII.L00-L08.L02   Abscess of skin, boil and carbuncle

    XII.L00-L08.L08.9   Local infection of skin and subcutaneous tissue, unspecified

    Contraindications:

    Acute infectious (nonsophilococcal etiology) and non-infectious diseases, including the period of convalescence, chronic diseases in the stage of exacerbation or decompensation;

    Diseases of the liver and kidneys.

    Treatment with staphylococcal vaccine is carried out not earlier than a month after recovery (remission).

    Additional contraindications for children aged 6 months to 6 years:

    allergic diseases - bronchial asthma, common eczema and neurodermatitis, recurrent asthmatic bronchitis, Quincke's edema;

    diseases of the central nervous system; rickets of II and III degree; grade II and III hypotrophy; disease of the endocrine system.

    Carefully:

    In case of prematurity (body weight at birth <2.5 kg), treatment is performed provided that the child achieves normal age indices. In contact with infectious patients in the family, children's institution, etc. the drug is administered after the end of the quarantine.

    Reaction to administration. At the injection site, skin hyperemia and minor soreness may develop. In some patients, the administration of the drug may be accompanied by an increase in temperature of 0.5-1 ° C. After the first two injections in inflammatory foci soreness may increase. With the development of a local or general reaction, the subsequent administration of the vaccine is carried out after the disappearance of the reaction at the same dose as the previous one. In the case of a pronounced reaction to the administration of the vaccine (a fever of 38 ° C or higher, a significant soreness in the inflammatory foci, an infiltration at the injection site of more than 20 mm in diameter), at the discretion of the attending physician,interval between injections to 2-3 days, repeat or reduce the dose with repeated injections.

    Pregnancy and lactation:

    Do not use in pregnant and lactating women.

    Dosing and Administration:

    Subcutaneously, in the shoulder region or in the subscapular region.

    The course of treatment for adults and children from 7 years of age consists of single daily injections according to the following scheme: Day 1 - 0.2 ml, 2nd - 0.3 ml, 3rd - 0.4 ml, 4th - 0.5 ml, the 5th - 0.6 ml, the 6th - 0.7 ml, the 7th - 0.8 ml, the 8th - 0.9 ml, the 9th - 1 ml.

    For children from 6 months to 7 years, the dose for the first injection is 0.1 ml. In the absence of the reaction, the drug is administered daily according to the scheme, successively increasing each dose by 0.1 ml (the second injection - 0.2 ml, the third - 0.3 ml, etc.). Each subsequent dose of the drug is administered at a distance of 20-30 mm from the site of previous injections or into the opposite arm.

    With common skin lesions that occur with relapses, it is advisable to repeat the course of treatment according to the same schedule after 10-15 days.

    Side effects:

    With the correct administration of the drug, taking into account contraindications, there are no complications after the introduction of the vaccine.

    Overdose:

    There are no reported cases of overdose. Treatment is symptomatic.Seek medical advice.

    Interaction:Clinically significant interactions are not established. Do not use together with drugs depressing immunity.
    Special instructions:

    The preparation is not suitable for use in ampoules with broken integrity, marking, changing physical properties (presence of opalescence, sediment), expired shelf life, improper storage. Opening of the ampoule with the vaccine and the vaccination procedure are carried out with strict adherence to the rules of aseptic and antiseptic. The vaccine in the opened ampoule should be used immediately.

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