Vaccine for the prevention of influenza [inactivated] - instructions for use, dose, side effects, contraindications

Forms high specific immunity against influenza. Protective titers of antibodies to influenza viruses after vaccination of persons of different ages are determined in 75-92% of vaccinated.

Pharmacokinetics:

No data.

Indications:

Prevention of influenza in adults and children older than 6 months (including with respiratory and cardiovascular diseases, chronic renal failure, diabetes, immunodeficiency, including infection with the human immunodeficiency virus, malignant blood diseases with concomitant therapy with immunosuppressants, cytostatics, radiation therapy, high doses of glucocorticosteroids); in elderly patients (over 65 years), in pregnant women at high risk of influenza.

ICD-10

XXI.Z20-Z29.Z25.1 The need for immunization against influenza

Contraindications:

Hypersensitivity, including chicken protein and aminoglycosides; allergic reactions to the previous administration of the vaccine; acute febrile conditions or exacerbation of a chronic disease (vaccination is given after recovery orremission); mild acute respiratory viral infections (vaccination is performed after normalization of body temperature).

Carefully:

Against the background of the lesser acute respiratory viral infections, acute intestinal diseases and other vaccinations are carried out after the normalization of body temperature.

On the day of vaccination, the vaccinated should be examined by a physician (paramedic) with obligatory thermometry. At a body temperature above 37 ° C, vaccination is not performed.

Vaccination offices should have anti-shock medications (epinephrine, glucocorticosteroids and others).

Pregnancy and lactation:

Preclinical studies have shown that the vaccine does not have embryotoxic and teratogenic effects. The decision on vaccination of pregnant women should be taken by a doctor individually, taking into account the risk of infection with influenza and possible complications of influenza infection. Vaccination is most safe in the II-III trimesters of pregnancy.

Does not have teratogenic and toxic effects on the fetus. Possible vaccination during lactation.

Dosing and Administration:

Intramuscularly, into the deltoid muscle or deeply subcutaneously in the upper third of the outer surface of the shoulder, young children - in the anterolateral surface of the thigh.

Children from 6 months to 3 years: 0.25 ml once; children who had not previously had the flu and unvaccinated - twice with an interval of 4 weeks.

Children over 3 years and adults: 0.5 ml once.

Patients with immunodeficiency can enter the vaccine twice in 0.25 ml at intervals of 4 weeks.

Side effects:

Often: headache, hyperthermia, malaise, fatigue, tremor, sweating, tenderness in muscles and joints, neuralgia (transiently, disappear after 1-2 days); rarely - thrombocytopenia, paresthesia, convulsions, encephalomyelitis, neuritis, Guillain-Barre syndrome (there is no clear connection with vaccination); very rarely - vasculitis with transient renal dysfunction, allergic reactions up to shock.

Local reactions: hyperemia, compaction, swelling and tenderness at the injection site, ecchymosis.

Overdose:

There is no reliable data.

Interaction:

The vaccine can be used concomitantly with other inactivated vaccines (contraindications to each of the vaccines used must be taken into account, drugs must be injected into different parts of the body, with different syringes).

Glucocorticosteroids and immunosuppressants reduce the immune response to the administration of the vaccine.

Special instructions:

Vaccination is carried out annually in the autumn-winter period. It is possible to vaccinate at the beginning of an epidemic rise in the incidence of influenza.

Intravenous administration is not allowed. After vaccination, it is possible to obtain false positive results of serological tests for enzyme-linked immunosorbent assays, which are caused by the production of IgM.

The drug may contain trace amounts of gentamicin.

Does not affect the ability to concentrate and the speed of the psychomotor reaction.

The vaccinated should be monitored by a health worker within 30 minutes after immunization.

The vials are opened and the vaccination procedure is carried out with strict adherence to aseptic and antiseptic rules: before opening the ampoule, the ampulla neck is wiped with cotton wool soaked with 70% ethanol, the ampoule is opened, the vaccine is taken into a disposable syringe and excess air is removed from the syringe. Ethanol wipe the skin at the injection site.

The drug in the opened ampoule is not subject to storage.

The preparation is not suitable for use in ampoules with broken integrity or marking, with a change in physical properties (color, transparency), with expired shelf life, if the requirements for storage conditions are violated.

Instructions

Vaccine for the prevention of influenza [inactivated] (Vaccinum ad prophylaxim grippi inactivatum)