Active substanceEszin + Essential phospholipids + Sodium HeparinEszin + Essential phospholipids + Sodium Heparin
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  • Venabos®
    gel externally 
    Boznalek, AO     Bosnia and Herzegovina
  • Dosage form: & nbspgel for external use
    Composition:

    1 g of gel contains:

    active ingredients: escin 10.0 mg, essential phospholipids 10.0 mg, sodium heparin 100.0 IU;

    Excipients: isopropanol 300.00 mg, glycerol 85% 20.00 mg, trolamine 10,80 mg, bactericide MB * 10,00 mg, carbomer 940 8.00 mg, cologne 0.70 mg, rosemary oil 0.40 mg, lavender oil 0.40 mg, water up to 1.00 g.

    * The MB bactericide contains: methyl parahydroxybenzoate 5.0-10.0%, ethyl parahydroxybenzoate 5.0 -10.0%, propyl parahydroxybenzoate -1.0-5.0%.

    These amounts of parabens are dissolved in butylene glycol.

    Description:

    Transparent, light-yellow gel with a characteristic odor.

    Pharmacotherapeutic group:Venotonizing agent
    ATX: & nbsp

    C.05.B.A.53   Heparin in combination with other drugs

    Pharmacodynamics:

    Combined drug, has a local anticoagulant, anti-inflammatory, venotonizing and antiaggregant effect, reduces the permeability of veins, improves microcirculation.

    Sodium Heparin - an anticoagulant of direct action; thanks to the inactivation of biogenic amines and the blocking of lysosomal enzymes in tissues, exhibits anti-inflammatory action, accelerates the dissolution of microthrombi in the region of the subcutaneous capillaries, prevents thrombogenesis,activates the fibrinolytic system; improves microcirculation, promotes regeneration of connective tissue due to inhibition of hyaluronidase activity.

    Phospholipids reduce the viscosity of blood due to the effect on fat metabolism, reduce the process of platelet aggregation.

    Eszin - Venotonizing agent of plant origin, Prevents the activation of lysosomal enzymes that cleave proteoglycan, increases the tone of the venous wall, eliminates venous stasis; reduces permeability and fragility of capillaries. Reduces exudation, reduces the effusion of fluid in the tissue and speeds up the resorption of the existing edema. It inhibits the processes of inflammation, improves microcirculation, contributes to the repair of organs and tissues.

    Pharmacokinetics:

    Information on the pharmacokinetics of escin and phospholipids in external application is absent. Sodium Heparin when topically applied quickly penetrates through the epidermis and accumulates in the upper layers of the skin. An insignificant amount of sodium heparin is absorbed from the surface of the skin into the systemic bloodstream (less than 0.2% of the total amount applied). The maximum concentration (Cmax) in the blood is noted 8 hours after the application. Sodium Heparin is excreted mainly with urine. The half-life (T1/2) is 12 h. After absorption, biotransformed in the liver and in the reticuloendothelial system.

    Indications:

    Varicose disease with symptoms in the form of pain, swelling, a feeling of heaviness in the legs, night cramps calf muscles, phlebitis, thrombophlebitis, post traumatic and postoperative hematomas without compromising the integrity of the skin.

    Contraindications:

    Hypersensitivity to the components of the drug, hemorrhagic diathesis (including thrombocytopenic purpura), hemophilia, violation of the integrity of the skin, age of 18 years. Do not apply on irradiated skin.

    Pregnancy and lactation:

    Application in pregnancy is possible only in cases where the expected benefit of therapy for the mother exceeds the potential risk to the fetus. Application in III trimester of pregnancy is contraindicated.

    If it is necessary to use lactation during breastfeeding, it is recommended to stop breastfeeding.

    Dosing and Administration:

    Outwardly.

    The gel is applied to the lesion site without rubbing into the skin, 2-4 times a day daily until the symptoms disappear. Duration of treatment - no more than 15 days.The possibility of a longer treatment is determined by the doctor.

    Side effects:

    Allergic reactions: urticaria, skin rash, skin itching.

    Overdose:

    Data on drug overdose are absent.

    Interaction:

    The drug should not be applied to the skin at the same time as other medicines for external use.

    Special instructions:

    Avoid contact with eyes and mucous membranes.

    When developing allergic reactions, the patient should immediately stop using the drug and consult a doctor.

    Form release / dosage:Gel for external use.
    Packaging:

    40.0 g per aluminum tube, sealed with a membrane and a screw cap made of polypropylene.

    The tube with instruction for use is placed in a cardboard box.

    Storage conditions:

    At a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiration date.

    Terms of leave from pharmacies:On prescription
    Registration number:LP-001044
    Date of registration:21.10.2011 / 20.10.2012
    Expiration Date:21.10.2016
    The owner of the registration certificate:Boznalek, AOBoznalek, AO Bosnia and Herzegovina
    Manufacturer: & nbsp
    BOSNALIJEK, d.d. Bosnia and Herzegovina
    Representation: & nbspBOSNALEK AO BOSNALEK AO Bosnia and Herzegovina
    Information update date: & nbsp24.01.2017
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