The frequency of side effects is classified according to the recommendations of the World Health Organization: very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely (including isolated cases) - less than 0.01%.From the immune system: infrequently - anaphylactic reaction, skin rash, itchy skin; rarely - hives, erythema.
From the nervous system: frequent-headache, increased excitability, irritability, sleep disturbances, drowsiness, fatigue, depression, dizziness.
From the cardiovascular system: infrequent increase in blood pressure; rarely thromboembolic disorders.
From the side of the organ of vision: rare-acute visual disorders, diplopia, exophthalmos.
From the respiratory system, chest and mediastinum: rarely - thromboembolism of the pulmonary artery.
From the skin and subcutaneous tissues: infrequently, acne, chloasma (hyperpigmentation of the facial skin in the form of yellowish-brown spots), alopecia.
From the gastrointestinal tract: often - nausea, rarely - cholestatic jaundice.
From the reproductive system and the breast: often - increased sensitivity of the nipples of the breast and mammary glands, tenderness of the mammary glands; infrequently - galactorrhea, menstrual irregularity, erosion and changes in vaginal discharge, amenorrhea.
Other: infrequently, weight gain, fatigue, symptomatic complex of Itenko-Cushing (obesity, lunar face, striae of different color, swelling of the lower limbs, decreased libido, hyperpigmentation of the skin in places of friction, decreased glucose tolerance and increased blood pressure), hyperthermia, a violation of the liver, rarely - hirsutism, cramps in the calf muscles.