Aprotinin is a polyvalent protease inhibitor, has antiproteolytic, antifibrinolytic and hemostatic action, it participates in blockade of the kallikrein-kinin system. In the development of opium withdrawal syndrome, an important role is assigned to hypercatecholamineemia.Long-term use of opiates causes hypersensitivity to dopaminergic, noradrenergic, serotonergic and cholinergic brain systems. A common link in the pharmacological action of substances that can cause a dependence syndrome is their effect on catecholamine neuromediation in the limbic region the brain. Aprotinin has an effect on the functioning of the depressor system (kallikrein-kinin), which regulates the mediated formation and disintegration of catecholamines; in this way, aprotinin blocks the process of pain and vegetative manifestations with abstinence syndrome.
In the basis of the formation of the opiate withdrawal syndrome along with the central mechanisms (the system of endogenous opiates), an important role is played by non-opioid peptides and larger polypeptide molecules. Decay of polypeptide molecules, The peptidases carried out, on the one hand, lead to the inactivation of active polypeptides, and, on the other hand, to the cleavage of inert precursors with the formation of biologically active peptide forms. Aprotinin, blocking the action of enkephalinases, increases the level of endogenous enkephalins, which causes decrease in the severity of withdrawal syndrome.