Active substanceInterferon alfa-2b human recombinantInterferon alfa-2b human recombinant
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  • Dosage form: & nbspgel for external and local use
    Composition:

    1 g of gel for external and local use contains:

    active substance: interferon alfa-2b human recombinant 36,000 ME;

    Excipients: alpha-tocopherol acetate 0.055 g, methionine 0.0012 g, benzoic acid 0.00128 g, citric acid monohydrate 0.001 g, sodium tetraborate decahydrate 0.0018 g, sodium chloride 0.004 g, human albumin 0.002 g, glycerol distilled (glycerol) 0 , 02 g, carmellose sodium 0.02 g, ethanol 95% 0.055 g, purified water up to 1 g.

    Description:

    Opaque gel-like mass of white with a grayish tinge.

    Pharmacotherapeutic group:Cytokine
    ATX: & nbsp

    L.03.A.B.05   Interferon alfa-2b

    Pharmacodynamics:

    Interferon alfa-2b human recombinant has immunomodulatory, antiviral and antiproliferative properties. Suppresses the replication of RNA and DNA-containing viruses. Immunomodulating properties of interferon, such as enhancement of phagocytic activity of macrophages, increase in specific cytotoxicity of lymphocytes to target cells cause its mediated antibacterial activity.

    In the presence of antioxidants, alpha-tocopherol acetate, citric and benzoic acids, the specific antiviral activity of interferon increases, its immunomodulating effect is increased, which makes it possible to increase the effectiveness of the body's own immune response to infectious agents.

    The drug has a pronounced local immunomodulatory effect and promotes the increase of locally formed antibodies of the class of secretory IgA, preventing fixation and reproduction of pathogenic microorganisms on the mucous membranes, which provides a preventive effect of the drug for the prevention of viral and other diseases.

    The gel base provides a prolonged effect of the drug. Antioxidants included in the formulation - alpha-tocopherol acetate, citric and benzoic acids have anti-inflammatory, membrane-stabilizing, regenerating properties, and also contribute to the preservation of the biological activity of interferon alfa-2b human recombinant.

    Indications:

    - In the complex therapy of acute respiratory viral infections, including influenza, frequent and prolonged acute respiratory viral infections, including those complicated by bacterial infection;

    - prevention of ARVI, including influenza;

    - in the complex therapy of recurrent stenosing laryngotraheobronchitis;

    - prevention of recurrent stenosing laryngotraheobronchitis;

    - in the complex therapy of acute and exacerbations of chronic recurrent herpetic infection of the skin and mucous membranes, including urogenital form of herpetic infection;

    - in the complex therapy of herpetic cervicitis.

    Contraindications:

    Hypersensitivity to any of the components of the drug.

    Pregnancy and lactation:

    Pregnancy and the period of breastfeeding are not a contraindication for the use of the drug due to very low absorption of components. During the period of breastfeeding, do not apply to the nipple and areola.

    Dosing and Administration:

    The drug is used topically and topically.

    In the complex therapy of acute respiratory viral infections, including influenza, prolonged and frequent acute respiratory viral infections, including those complicated by bacterial infection:

    a strip of gel with a length of not more than 0.5 cm is applied to the previously dried surface of the nasal mucosa and / or to the surface of the palatine tonsils 3-5 times a day with a spatula or cotton swab / cotton swab (see note).The course of treatment is 5 days, if necessary, the course can be extended.

    Prevention of acute respiratory infections, including influenza: in the period of recovery incidence of a strip of gel length of not more than 0.5 cm is applied to the previously dried surface of the nasal mucosa and / or to the surface of the palatine tonsils 2 times a day for 2-4 weeks.

    In the complex therapy of recurrent stenosing laryngotraheobronchitis: a strip of gel not more than 0.5 cm long is applied to the surface of the tonsils using a spatula or cotton swab / cotton swab in the acute period of the disease 5 times a day, for 5-7 days, then 3 times a day for the next 3 weeks .

    Prevention of recurrent stenosing laryngitisracheobronchitis: a strip of gel with a length of no more than 0.5 cm is applied to the surface of the tonsils using a spatula or a cotton swab / cotton swab 2 times a day for 3-4 weeks, the courses are repeated 2 times a year.

    In the complex therapy of acute and chronic recurrent herpetic infection (with the appearance of the first signs of the disease or during the precursors): a strip of gel long no more than 0.5 cm is applied with a spatula or cotton swab / cotton swab on the pre-dried affected surface 3-5 times a day for 5-6 days,if necessary, the duration of the course is increased until the disappearance of clinical manifestations.

    In the complex therapy of herpetic cervicitis: 1 ml of the gel is applied with a cotton swab on the pre-cleaned surface of the cervix 2 times a day for 7 days, if necessary, the duration of the course can be increased to 14 days.

    Note. On the mucous membrane of the nasal cavity, the gel is applied after cleansing the nasal passages, on the surface of the tonsils - 30 minutes after eating. When applying the gel to the palatine tonsils, do not touch the tonsils with a cotton swab, but only with gel, while the gel itself flows down the surface of the amygdala. When applying the gel to the cervix, you must first remove the mucus and gauze swab and mucus discharge from the vaults of the vagina and cervix.

    When applying the gel to the affected skin and mucous membranes after 30-40 minutes a thin film is formed, on which the drug is again applied. If desired, the film can be peeled off or washed off with water before re-applying the preparation. The opened tube is stored in the refrigerator for no more than 2 months.The preparation with the broken integrity of packing and the changed color is not suitable for use.

    Side effects:

    In rare cases, it is possible to develop allergic reactions (skin rashes, itching).

    Overdose:

    Not installed.

    Interaction:

    Not found.

    Effect on the ability to drive transp. cf. and fur:

    Not installed.

    Form release / dosage:Gel for external and local application, 36000 IU / g.
    Packaging:

    For 12 g in an aluminum tube.

    1 tube with instructions for use in a pack of cardboard.
    Storage conditions:

    At a temperature of 2 to 8 ° C.

    Keep out of the reach of children.

    Shelf life:1 year.
    Do not use the drug after the expiration date.

    Terms of leave from pharmacies:Without recipe
    Registration number:P N001142 / 02
    Date of registration:13.04.2010 / 25.10.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:FERON, LLC FERON, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp25.03.2017
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