Virollex (Virolex)

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Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspointment eye
Composition:1 g ointment ophthalmic contains:

Active substance:

Acyclovir 30.00 mg

Excipients:

Vaseline White 970.00 mg

Description:

Homogeneous slightly transparent oily ointment without odor, white or almost white.

Pharmacotherapeutic group:Antiviral for topical use
Pharmacodynamics:

Acyclovir is an antiviral agent from the group of synthetic analogs of acyclic purine nucleoside, deoxyguanidine, which is a component of DNA.

Acyclovir is active against Herpes simplex 1 and 2 types, virus Varicella zoster, the Epstein-Barr virus and cytomegaloviruses. Thymidine kinase virus-infected cells through a series of consecutive reactions actively converts acyclovir in mono-, di- and triphosphate of acyclovir. The latter interacts with the viral DNA polymerase and is embedded in DNA, which is synthesized for new viruses. Thus, "defective" viral DNA is formed, which leads to suppression of replication of new generations of viruses.

Pharmacokinetics:

Easily penetrates the epithelium of the cornea and creates a therapeutic concentration in the eye fluid.

Indications:

Herpetic keratitis.

Contraindications:

Hypersensitivity to acyclovir or other components of the drug.

Pregnancy and lactation:Since the effectiveness and safety of treatment with acyclovir in children, during pregnancy and lactation are not established, it is not recommended to use the drug in these categories of patients.
Dosing and Administration:

Locally. One centimeter of ophthalmic ointment is inserted into the lower conjunctival sac 5 times a day at 4-hour intervals. The duration of treatment is usually 7-10 days, with interstitial forms - up to 10-20 days.

After healing acyclovir must be appointed for at least three more days.

Side effects:

Very rarely arise:

Local: slight burning sensation at the application site, blepharitis, conjunctivitis, superficial keratopathy (does not require cessation of treatment and disappears without consequences), pain in the eyes, itching of the skin around the eyes, skin rash, erythema of the skin around the eyes, mild dryness of the mucous membrane of the eye.

Overdose:

There is no evidence of an overdose with topical application. Since absorption of acyclovir is possible in minimal amounts, the probability of systemic action is not ruled out.

Symptoms in systemic application: headache, neurological disorders, dyspnea, nausea, vomiting, diarrhea, impaired renal function, lethargy, convulsions, coma.

Treatment: symptomatic; maintenance of vital functions, hemodialysis.

Interaction:An increase in the effect is noted with the simultaneous appointment of immunostimulants.
Special instructions:

The effectiveness of treatment will be higher the earlier it was started.

In patients with immunodeficiency with repeated repeated courses of treatment, the formation of virus resistance to acyclovir sometimes occurs. To prevent autoinoculation to other areas of the skin, use fingertips or rubber gloves.

During therapy with the drug, you should not wear contact lenses.

Form release / dosage:

Eye ointment 3%.

Packaging:

4.5 g of the drug in an aluminum tube with a screwed plastic lid. 1 tuba is packed in a pack of cardboard along with instructions for use.

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years.

Do not use after the expiration date.

Terms of leave from pharmacies:Without recipe
Registration number:П N014287 / 01
Date of registration:15.01.2013
Expiration Date:Unlimited
Date of cancellation:2017-04-28
The owner of the registration certificate:KRKA, dd, Novo mesto, AOKRKA, dd, Novo mesto, AO
Manufacturer: & nbsp
KRKA, d.d. Slovenia
Representation: & nbspKRKA, dd, Novo mesto, AOKRKA, dd, Novo mesto, AO
Information update date: & nbsp28.04.2017
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