Vitamin E (Vitamin E)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbspcapsules
Composition:

1 capsule contains:

Active substance: alpha-tocopherol acetate 200 mg and 400 mg;

Excipients: sunflower seed oil is sufficient until the contents of the 300 mg and 600 mg capsule are obtained.

Composition of gelatin capsule shell for dosing 200 mg: gelatin 113.44 mg, glycerol (glycerol) 51.94 mg, purified water 14.4 mg, sodium benzoate E-211 0.22 mg.

The composition of the gelatin capsule shell for a dosage of 400 mg: gelatin 119.74 mg, glycerol (glycerin) 54.83 mg, water purified 15.2 mg, sodium benzoate E-211 0.23 mg.

Weight capsules for dosing 200 mg - 480 mg.

Weight capsules for dosing 400 mg - 790 mg.

Description:

Capsules soft gelatinous, oval in shape, with a seam of light yellow color.

The contents of the capsules are an oily liquid of light yellow color. The presence of a rancid odor is not allowed.

Pharmacotherapeutic group:Vitamin
ATX: & nbsp
  • Tocopherol (vitamin E)
    • Pharmacodynamics:

    Fat-soluble vitamin, the function of which remains unclear until the end. As an antioxidant, inhibits the development of free radical reactions, prevents the formation of peroxides that damage cellular and subcellular membranes, which is important for the development of the body. Together with selenium, it inhibits the oxidation of unsaturated fatty acids (a component of the microsomal electron transfer system), prevents the hemolysis of erythrocytes. It is a cofactor of some enzyme systems.

    Pharmacokinetics:

    Absorption from the duodenum (necessary presence of bile salts, fats, normal functioning of the pancreas) - 20-40%. When the dose is raised, the degree of absorption decreases. Time to reach the maximum concentration is 4 hours. It is deposited in all organs and tissues, especially in adipose tissue, penetrates through the placenta in insufficient quantities: 20-30% of the concentration in the blood of the mother penetrates into the fetal blood. Penetrates into breast milk. Excretion mainly through the gastrointestinal tract, with bile - more than 90%, less than 6% is excreted by the kidneys in the form of glucuronides and other metabolites.

    Indications:

    Treatment of hypo- and avitaminosis E.

    Contraindications:

    - Hypersensitivity;

    - acute myocardial infarction;

    - childhood.

    Carefully:

    With caution should be used in severe cardiosclerosis, after a heart attack, with an increased risk of thromboembolism, as well as hypoprothrombinemia (against a background of vitamin K deficiency - may increase with a dose of vitamin E more than 400 mg).

    Pregnancy and lactation:

    Vitamin E is used during pregnancy and during breastfeeding only as prescribed by the doctor.

    Dosing and Administration:

    Capsules 200 mg: adults 1-2 capsules per day.

    Capsules 400 mg: adults 1 capsule per day.

    The duration of treatment is determined by the doctor depending on the severity of the condition.

    It is not recommended to appoint for a long time in conjunction with other multivitamin preparations, tk. possibly the onset of an overdose of fat-soluble vitamin E.

    Side effects:

    Allergic reactions.

    When taking large doses - diarrhea, epigastric pain, creatinuria, dyspepsia.

    If there are side effects, the dose of the drug should be reduced or canceled.

    Overdose:

    Symptoms: when taken for a long period in doses of 400-800 mg / day - blurred vision, dizziness, headache, nausea, unusual fatigue, diarrhea, gastralgia, asthenia; when taking more than 800 mg / day for a long period - an increased risk of bleeding in patients with hypovitaminosis K, a disorder of thyroid hormone metabolism, a sexual function disorder, thrombophlebitis, thromboembolism, necrotic colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, haemorrhage a covering of an eye, a hemorrhagic insult, an ascites, a hemolysis.

    Treatment: drug cancellation; prescribe glucocorticoids, which accelerate the metabolism of vitamin E in the liver; appoint Vikasol to reduce the risk of hemorrhages.
    Interaction:

    Enhances the effect of steroid and non-steroidal anti-inflammatory drugs, antioxidants.

    Increases the efficiency and reduces the toxicity of cardiac glycosides.

    The appointment of vitamin E in high doses can cause vitamin A deficiency in the body.

    Simultaneous use of vitamin E at a dose of more than 400 mg / day with anticoagulants (coumarin and indanedione derivatives) increases the risk of hypoprothrombinemia and bleeding.

    Colestramine, colestipol, mineral oils reduce the absorption of alpha-tocopherol acetate.

    With the simultaneous use of vitamin E with cyclosporin, the absorption of the latter increases.

    Special instructions:

    It is necessary to strictly follow the dosing regimen.

    With congenital bullous epidermolysis in areas affected by allopecia, white hair may begin to grow.

    With long-term use of the drug and / or the need to prescribe repeated courses of therapy, it is recommended to periodically monitor blood coagulation indicators, as well as the level of cholesterol in the blood.

    Effect on the ability to drive transp.cf. and fur:

    Does not affect.

    Form release / dosage:

    Capsules, 200 mg and 400 mg.

    Packaging:

    10 capsules per contour cell packaging made of polyvinylchloride film and aluminum foil printed lacquered.

    For 3 or 6 contour squares, together with the instruction, they are put in packs of cardboard.

    Storage conditions:

    Store in a dry, dark place at a temperature of 15 to 25 ° C.

    Store in a place inaccessible to children.

    Shelf life:

    2 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-002149
    Date of registration:17.07.2013
    Expiration Date:17.07.2018
    Date of cancellation:2018-07-17
    The owner of the registration certificate:MINSKINTERKAPS, UP MINSKINTERKAPS, UP Republic of Belarus
    Manufacturer: & nbsp
    MINSKINTERKAPS, UP Republic of Belarus
    Information update date: & nbsp21.02.2017
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