Iodine + [Potassium iodide + Polyvinyl alcohol] - instructions for use, dose, side effects, contraindications

Elementary iodine has pronounced antimicrobial properties. For preparations of elemental iodine, a pronounced local irritant effect on tissues is characteristic, and cauterizing effect in high concentrations. Local action is due to the ability of elementary iodine to precipitate tissue proteins. Preparations, eliminating the elementary iodine, have a much less pronounced irritant effect, and iodides have locally irritating properties only at very high concentrations.

The nature of the resorptive action of preparations of elemental iodine and iodides is the same. The most pronounced effect with resorptive action iodine preparations have on the functions of the thyroid gland.With iodine deficiency, iodides contribute to the restoration of impaired thyroid hormone synthesis. With normal iodine content in the environment, iodides inhibit the synthesis of thyroid hormones, reduce the sensitivity of the thyroid gland to thyroid-stimulating hormone pituitary gland and its pituitary secretion is blocked. The effect of iodine preparations on metabolism is manifested by the intensification of dissimilation processes. With atherosclerosis, they cause a slight decrease in the concentration of cholesterol and beta-lipoproteins in the blood; in addition, increase the fibrinolytic and lipoproteinase activity of blood serum and slow the rate of blood clotting.

Accumulating in syphilitic scales, iodine promotes their softening and resorption. However, the accumulation of iodine in tuberculosis foci leads to an intensification of the inflammatory process in them. Isolation of iodine excretory glands is accompanied by irritation of glandular tissue and increased secretion. This is due to expectorant action and stimulation of lactation (in small doses). However, in large doses of iodine preparations can cause suppression of lactation.

Pharmacokinetics:When exposed to skin or mucous membranes, 30% turns into iodides, and the rest into active iodine. Partially absorbed. The absorbed part penetrates into tissues and organs, is selectively absorbed by the thyroid gland. It is allocated mainly by the kidneys, intestines, sweat and mammary glands.

Indications:Chronic tonsillitis, purulent otitis, purulent surgical diseases, chronic periodontitis, trophic and varicose ulcers, thermal and chemical burns of I and II degrees.

ICD-10

VIII.H65-H75.H66 Purulent and unspecified otitis media

IX.I80-I89.I83.2 Varicose veins of the lower extremities with ulcer and inflammation

X.J00-J06.J03.9 Acute tonsillitis, unspecified

X.J30-J39.J31 Chronic rhinitis, nasopharyngitis and pharyngitis

X.J30-J39.J35.0 Chronic tonsillitis

XII.L80-L99.L87 Transepidermal perforated changes

XIX.T08-T14.T14.0 Superficial injury of unspecified area of the body

XIX.T08-T14.T14.1 Open wound of unspecified area of the body

XIX.T20-T32.T30 Thermal and chemical burns, unspecified

XIII.M70-M79.M79.1 Myalgia

Contraindications:Hypersensitivity to iodine. For oral administration - pulmonary tuberculosis, nephritis, nephrosis, adenomas (including thyroid gland), furunculosis, acne, chronic pyoderma, thyrotoxicosis, herpetiform dermatitis,hemorrhagic diathesis, urticaria, pregnancy, the period of breastfeeding, perforation of the tympanic membrane.

Carefully:Children under 18 years.

Pregnancy and lactation:

The category of recommendations is not defined. Not recommended locally - the risk of hypothyroidism and goiter in a child.

Penetrates into milk with local use.

Dosing and Administration:Locally.

In chronic tonsillitis, wash (50 ml) lacunae of tonsils and supratonsillare space, 4-5 washes with an interval of 2-3 days; with purulent otitis daily for 2-4 weeks instilled in the ear 5-8 drops; atrophic rhinitis after preliminary softening and removal of crusts are inhaled into the nasal cavity and throat 2-3 times a week for 2-3 months; with trophic and varicose ulcers, purulent wound surfaces and infected burns, festering fistulas impose loose gauze bandages impregnated with the drug.

Side effects:

For external use: rarely - skin irritation; with prolonged use on extensive wound surfaces - iodism (rhinitis, urticaria, Quincke's edema, salivation, lacrimation, acne).

Ingestion: skin allergic reactions, tachycardia, nervousness, sleep disorders, excessive sweating, diarrhea (in patients older than 40 years).

Overdose:

When concentrated solutions get inside - severe burns of the digestive tract of the esophagus (with the subsequent development of strictures), hemolysis, hemoglobinuria; The lethal dose is about 3 g.

If you accidentally swallow unconcentrated solutions: abdominal pain, anuria, diarrhea with blood, severe thirst, fever, nausea, vomiting, metallic taste in the mouth. Shock, tachycardia, metabolic acidosis, renal failure. A fatal outcome is possible due to vascular insufficiency, epiglottis edema and asphyxia, aspiration pneumonia or pulmonary edema.

Treatment (if patient is conscious) - take milk every 15 minutes or a starch / flour solution (at the rate of 15 mg of starch or flour for 500 ml of water) to absorb unboiled iodine. You can also use Activated carbon and sodium thiosulfate (usually 1% solution) inside to transfer iodine to less toxic iodides. Gastric lavage is not recommended, as there is no certainty that even sufficiently weak iodine solutions can not cause a burn of the esophagus.To maintain the basic functions of the body - oxygen therapy, antihistamines, epinephrine and corticosteroids - with anaphylactic shock.

Interaction:Pharmaceutically incompatible with essential oils, solutions of ammonia, white sedimentary mercury (an explosive mixture is formed). Alkaline or acidic medium, the presence of fat, pus, blood weaken antiseptic activity. Weaken the hypothyroid and strugogenic effects of lithium preparations.

Special instructions:With prolonged use, the phenomena of iodism are possible. Avoid contact with eyes. If this happens, the eyes should be washed with a large amount of water or 1% with a solution of sodium thiosulfate.

Instructions

Iodine + [Potassium iodide + Polyvinyl alcohol] (Iodum + [Kalii iodidum + Spiritus polyvinylicus])