Included in the formulation
АТХ:V.08.A Radiocontrast iodine-containing substances
Pharmacodynamics:Radiopaque ion diagnostic tool.It is a triiodide-containing compound. Organic iodine compounds absorb X-rays and, selectively accumulating in separate structures of the body, provide a high degree of their opacity, highlighting them against the background of other structures that do not contain iodine. The degree of contrast is directly proportional to the concentration of the iodine-containing contrast agent in the tissue. After intravascular injection, the blood vessels are consistently contrasted. Causes visualization of vessels, cavities and urinary tract during X-ray examination.
Pharmacokinetics:After intravenous administration, it circulates in the vascular bed and is excreted in the urine by glomerular filtration and secretion in the renal tubules.
Indications:Angiography, aortography, angiocardiographyI, peripheral arteriography, phlebography, selective angiography, cerebral angiography, urography.
XXI.Z00-Z13.Z03 Medical surveillance and evaluation in case of suspected disease or pathological condition
Contraindications:Hypersensitivityliver failure, kidney failure, thyrotoxicosis, tuberculosis (active form), myocardial damage,myeloma (multiple myeloma), arterial hypertension, shock, collapse, hypercoagulation, hyperprothrombinmia, acute phlebitis (for venography).
Carefully:Dehydration, especially due to kidney disease, severe vascular disease, diabetes, elderly age, hyperthyroidism, nodal goiter, hypersensitivity to iodine-containing contrast media in history, myeloma (multiple myeloma), hypertensive disease in the stage of decompensation, local infectious processes, severe tissue ischemia, phlebitis, thrombosis, venous stasis, a significant increase in blood clotting, systemic venous obstruction, chronic heart failure.
Pregnancy and lactation:The category of recommendations is not defined. Adequate and well-controlled studies in animals and in humans have not been carried out.
There is no information on the penetration into breast milk. It is recommended to temporarily stop breastfeeding after the administration of iodamide.
Dosing and Administration:Individual, depending on the indications and the dosage form used.Enter intra-arterially, intravenously, use intracavitary injection and injection into the bladder.
Iodamid-380 - in the peripheral vein (phlebography) 1 ml / kg (but not more than 100 ml) at a rate of 0.3-25 ml / s, directly into the heart cavity - 30-50 ml; intraarterially (aortography, arteriography) - 0.5-1 ml / kg; X-rays are taken 5-10 minutes after the injection. For intracavitary injection, dilute in an isotonic solution of sodium chloride or 5% glucose to obtain a 30% solution; retrograde injected into the urinary tract 6-8 ml (under X-ray visual control), in the bladder - 100-200 ml. For cerebral angiography, only iodamide-300 is used, 6-10 ml is injected at a rate of 5-10 ml / s.
Excretory urography: intravenously 20 ml of a solution with an equivalent concentration of iodine 380 mg / ml or 40 ml of a solution with an equivalent concentration of iodine 300 mg / ml (at a rate of 0.3-0.5 ml / s). Radiography is performed 5-10 minutes after the injection.
Retrograde urography: in the urinary tract 6-8 ml (under X-ray visual control), in the urinary bladder - 100-200 ml.
Side effects:Feeling of heat, dizziness, nausea, vomiting, tachycardia, cyanosis. Less commonly - increased salivation, lacrimation, erythematous rashes, hives, anaphylactoid reaction and anaphylactic shock, itchy exanthemes.Very rarely - bronchospasm, Quincke's edema, arterial hypotension, collapsoid states, arrhythmia, ventricular fibrillation, cardiac arrest, pulmonary edema, neurologic disorders (epileptiform seizures), lupus medication syndrome, hyperthyroidism, thrombophlebitis.
Overdose:Not described. Treatment symptomatic.
Interaction:Against the background of levothyroxine sodium increases the risk of developing thyrotoxic manifestations (relative overdose).
Against metformin, a sudden change in renal function is possible; patients who are scheduled for X-ray examination using parenterally administered iodamide, metformin must be temporarily canceled.
Special instructions:It should be strictly observed the compliance of a certain dosage form of iodamide and indications for its use. It should be noted that with increased sensitivity to the drug or with its overdose, arrhythmias, ventricular fibrillation, and cardiac arrest are possible. With heart failure, violations of the coronary circulation, and after a recent myocardial infarction, use only for vital indications, since the introduction of iodamide into the bloodstream causes an increased stress on the heart.Patients who are prone to allergic reactions, for several days before the administration of iodamide, should be prescribed antihistamines.