The study is performed on an empty stomach. To reduce the radiation load 2-3 days before the test, it is necessary to conduct a blockade of the thyroid gland with Lugol solution (5 drops 3 times a day).
Preparation of the drug is carried out in aseptic conditions by the addition of Iodofen, 123I dropwise to a 10% solution of albumin heated to 40 ° C in a ratio of 1:10 with constant stirring and subsequent sterilization of the resulting solution by filtration through a sterilizing filter "Millipore" (0.22 μm) or the like.
The sterile solution of Iodofen, 123I in albumin is administered to the patient intravenously, slowly, in the patient's lying position. Recommended doses 110-185 MBK.
SPECT is carried out after 20-30 minutes and after 4 hours to assess the rate of excretion of RFP from the myocardium.
For SPECT, a rotary gamma camera is used. Quality control of equipment - according to the generally accepted methodology. Adjustment of the amplitude analyzer is 159 keV, the window is 20%.
It is necessary to use a collimator for energy above 150 keV, because the bremsstrahlung X-ray radiation of the continuous spectrum ("lead X-ray"), formed as a result of the interaction of gamma quanta with the collimator material,It is not absorbed by the walls of a standard "technetium" collimator and creates intense interference when visualizing the image.
The system of data collection and processing is either imported or domestic with a package of programs for SPECT. The image matrix is at least 64 x 64 px.
Evaluation of the distribution pattern of RFPs on tomograms in longitudinal horizontal, longitudinal vertical and transverse planes and the polar map is similar to the evaluation of SPECT myocardium with perfusion RFP ("Technetril", thallium preparations).
The informative value of the method is significantly increased if the study of myocardial metabolism with the help of Iodophen, 123I is combined with the study of perfusion with the use of conventional techniques and technetium or thallium preparations. In this case, analogous segments are compared on the metabolic and perfusion polar maps, and they are distinguished:
1. The normal level of accumulation of both RFPs;
2. Uncoordinated accumulation defects with a predominance of perfusion or metabolic RFP, which corresponds to an ischemic but viable myocardium;
3. Consistent defects of perfusion and metabolism with an equally sharp decrease in the accumulation level of both RFPs,indicating the presence of scar tissue or areas of nonviable myocardium.
It is possible to conduct research in the technique of planar scintigraphy.
Radiation stress on the organs and the whole body with the application of "Yodofen, 123I "
| Organ | Equivalent dose, mGy / MBq |
| A heart | | 0,057 |
| Gonads (m) | | 0,008 |
| The gonads (g) | | 0,012 |
| Whole body (effective equivalent dose, mSv / MBq) | 0,01 |