Gelatinol® (Gelatinol®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceGelatinGelatin
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    solution d / infusion 
    SAMSON-MED, LLC     Russia
    • Dosage form: & nbspsolution for infusions
    Composition:

    In 1000 ml contains:

    Gelatin food, subjected to special treatment - 80g., Sodium chloride - 9.0g.

    Description:

    A sterile 8% colloidal solution of a partially digested, denatured gelatin protein with an average molecular weight of 15,000 to 25,000 with the addition of a sodium chloride solution, which is a clear amber-colored, colloidal solution with a specific odor that is highly foaming when agitated.

    Pharmacotherapeutic group:Plasmasuberant
    ATX: & nbsp
  • Preparations of gelatin
    • Pharmacodynamics:

    Gelatinol is a hypertonic colloidal solution with anti-shock effect. The therapeutic effect of gelatin is associated with the high colloid osmotic pressure created by it in the lumen of the blood vessels (220-290 mm of water). An increase in the volume of circulating plasma (more than 1.5 times the outgoing value) and an increase in arterial pressure occurs not only due to the introduced solution, but also in connection with the additional interstitial fluid entering the vascular bed.

    Gelatinol increases the rate of erythrocyte sedimentation, which normalizes on the average by the 20th day; does not violate the protein, carbohydrate and pigmentary functions of the liver; improves microcirculation.

    Pharmacokinetics:

    Gelatinol quickly leaves the bloodstream, which is explained by the presence of a large number of low molecular weight fractions (after 2 hours, approximately 20% of the injected drug remains in the blood). The bulk of the drug is excreted from the body by the kidneys (on the first day about 40% of the drug, in the second - 1%). The rest penetrates from the vascular bed into the tissue, where it is exposed to tissue enzymes - proteases and is included in the protein metabolism.

    Indications: As a plasma-substituting agent in the treatment of shock (traumatic, burn, hemorrhagic and toxic 1-2 levels); for filling in apparatus artificial blood circulation; from the goal detoxification with burns and other conditions, accompanied by intoxication.

    Contraindications:

    Hypersensitivity to the drug, acute and chronic nephritis.

    Carefully:

    Chronic renal failure, hemorrhagic diathesis, pulmonary edema, hypokalemia, hypernatremia,the state of dehydration (in this case, first of all correction of the water-electrolyte balance is required), chronic liver diseases in which albumin synthesis and coagulation factors are disrupted, and the introduction of the colloid solution will lead to further dilution.

    Pregnancy and lactation:

    There were no cases of embryotoxic action of the drug, but the possibility of allergic reactions can not be ruled out completely. In pregnancy, the drug should be administered when the possible benefit to the mother exceeds the potential risk to the fetus.

    There are no data on the penetration of the drug in mother's milk.

    Dosing and Administration:

    The drug is administered intravenously or intraarterially, regardless of the blood group.

    In case of acute blood loss and shock, a jet intravenous injection is recommended with a subsequent transition to a drop (50-60 drops per minute) to maintain blood pressure at the physiological level. The dose of the drug depends on the patient's condition. If necessary, gelatin is administered repeatedly. At the same time, no more than 2 liters of solution can be introduced. Children - at the rate of no more than 15-25 mg / kg body weight.

    For extracorporeal circulation, gelatinol is used together with donor erythrocytes in various ratios and with the addition of other solutions.

    Side effects:

    Albuminuria (within 1-2 days after administration). In very rare cases, the occurrence of allergic reactions of varying severity. It should be borne in mind the danger of developing anaphylactic shock in patients at risk who have a history of intolerance to drugs, including sera, vaccines, and intravenous fluids, plasma-substituting drugs, including dextran.

    If unwanted reactions occur, stop the infusion immediately and insert antihistamine, vasoconstrictors and glucocorticosteroids, vasopressor drugs used to treat anaphylactic shock without removing needles from the vein.

    Overdose:

    The main risk of overdose is associated with the possibility of circulatory overload, which in the future can adversely affect the function of the heart and lungs.

    If symptoms of circulatory congestion occur, discontinue the infusion immediately after the overdose!

    Interaction:

    Compatible with nitrogen-containing preparations for parenteral nutrition, vitamins, glucose solution in various proportions, blood and its components.

    Special instructions:

    Before transfusing gelatin, the doctor should perform a visual inspection of the bottles intended for infusion. The preparation is considered suitable for use provided that the sealing is kept tight, there is no cracks on the bottles. The drug should be clear and not contain suspended matter. The results of visual inspection of bottles and label data (name of the drug, manufacturer, serial number) must be recorded in the patient's medical history.

    When applying gelatin, a biological sample is mandatory: after the first 5 drops are injected, the infusion is stopped for 3 minutes, and then another 30 drops are added and the infusion is stopped again for 3 minutes, in the absence of an undesired reaction, the administration of the drug is continued. The results of the test must be recorded in the medical history.

    Effect on the ability to drive transp. cf. and fur:Not specified.
    Form release / dosage:

    Solution for infusion.

    Packaging:For 450 ml in bottles of glass, ukuporennyh rubber stoppers and rolled aluminum caps. By 15 bottles from 10 instructions for use in cardboard boxes.
    Storage conditions:In a dry place at a temperature of 4-22 ° C.
    Keep out of the reach of children.
    Shelf life:4 years. The drug should be used before the date indicated on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:P N001285 / 01-2002
    Date of registration:20.08.2008
    Expiration Date:Unlimited
    The owner of the registration certificate:SAMSON-MED, LLC SAMSON-MED, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp17.05.2017
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