Side effects of zoledronic acid are usually minor and transient, similar to side effects noted with the use of other bisphosphonates. In / in infusion is often accompanied by a fever. Often, patients develop an influenza-like syndrome, including fever, chills, fever, bone pain and / or arthralgia, myalgia. After IV introduction, reactions from the digestive tract, such as nausea and vomiting, are noted.Local reactions at the site of administration, such as redness or swelling, are less than in 1% of patients. In most cases, the symptoms disappear within 24-48 hours without specific treatment.
It has been reported rare cases of skin rash, itching and chest pain after the administration of zoledronic acid.
Just as with the use of other bisphosphonates, cases of conjunctivitis and hypomagnesemia have been reported.
The incidence of adverse reactions is classified according to WHO recommendations: very often - not less than 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0,1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01% (including single cases or at an unset frequency).
On the part of the digestive system: often - nausea, vomiting; infrequently - abdominal pain, constipation, diarrhea; frequency is not established - stomatitis, dryness of the oral mucosa, dyspepsia, inflammation of the gastrointestinal mucosa.
From the side of the blood and lymphatic system: often - anemia; infrequently - thrombocytopenia; rarely - pancytopenia; frequency is not established - granulocytopenia, neutropenia.
From the laboratory indicators: very often - hypophosphatemia; often - hypocalcemia; infrequently - hypokalemia, hypomagnesemia.
From the side of metabolism: dehydration, anorexia, increased sweating.
From the musculoskeletal system: arthralgia, muscle cramps, asthenia, bone pain, muscle pain, back pain, pain in the limbs.
From the nervous system: often - headache, confusion; infrequently - dizziness, hypoesthesia, hyperesthesia, paresthesia; frequency not established - anxiety, nervousness, anxiety, irritability, sleep disturbance, depression, hallucinations, drowsiness, dizziness, taste perversion, insomnia, tremor, anxiety.
From the cardiovascular system: infrequently - arterial hypotension; rarely - aetiology.
From the respiratory system: infrequently - shortness of breath, cough; frequency is not established - a pleural effusion, a pain in a thorax.
From the skin: frequency not established - alopecia.
Allergic reactions: infrequently - itchy skin; frequency is not established - dermatitis, angioedema.
From the genitourinary system: often - renal dysfunction; infrequently - hematuria, proteinuria.
From the musculoskeletal system: often - pain in the joints, pain in the bones of myalgia; frequency is not established - pain in the back area, pain in the chest.
On the part of the organs of vision: often - conjunctivitis; infrequently - blurred vision; very rarely - episcleritis, uveitis.
Benign, malignant and unspecified neoplasms (including cysts and polyps): frequency is not established - complication of the course and progression of malignant formation.
Infectious diseases: frequency is not established - candidiasis, infectious diseases of the upper respiratory tract, infectious diseases of the urinary tract.
Other: often - the flu-like syndrome; infrequently - asthenia; frequency is not established - peripheral edemas, hyperthermia, fast fatigue.