Included in the formulation
АТХ:R.06.A.X Other antihistamines for systemic use
Pharmacodynamics:Combined drug.
Mebrogroline
Blocks H1-gistaminovye receptors, has anti-allergic, antipruritic, m-holinoblokiruyuschee, sedative effect. Reduces the swelling of the mucous membrane.
Zinc sulfate
Interacts with cells of the mucosa, compacts colloids of extracellular fluid, exudate, mucus, forming a continuous film that protects from irritation of the end of the sensory nerves. Thus, it protects the mucous membrane from inflammation and prevents the irritating effect of the mebhydrolin.
Pharmacokinetics:Mebrogroline
After oral administration, an empty stomach is absorbed in the gastrointestinal tract up to 50%. The maximum concentration in the blood plasma is achieved in 1-2 hours. The connection with plasma proteins is 90%.
Therapeutic effect develops 15-30 minutes after the start of the procedure and lasts for 48 hours. Metabolism in the liver.
The half-life is 4 hours. Elimination by the kidneys.
Zinc sulfate
Local agent is not absorbed into the bloodstream and does not have a systemic effect on the body.
Indications:It is used to treat acute seasonal or all-year-round allergic conjunctivitis and rhinitis.Used for hay fever, hives, eczema, insect bites.
X.J30-J39.J30 Vasomotor and allergic rhinitis
VII.H10-H13.H10.1 Acute atopic conjunctivitis
X.J30-J39.J30.1 Allergic rhinitis caused by pollen of plants
X.J30-J39.J30.2 Other seasonal allergic rhinitis
X.J40-J47.J45 Asthma
XII.L20-L30.L20.8 Other atopic dermatitis
XII.L20-L30.L29 Itching
XII.L50-L54.L50 Hives
Contraindications:Peptic ulcer of the stomach and duodenum in the period of exacerbation, age to 1 year, pregnancy and lactation, prostatic hyperplasia, individual intolerance.
Carefully:Epilepsy, heart rhythm disturbances, closed angle glaucoma, renal and hepatic insufficiency, pyloric stenosis, hypersensitivity.
Pregnancy and lactation:Recommendations for FDA - Category C. Contraindicated in pregnancy and lactation.
Dosing and Administration:Use in children
Inside after a meal, depending on the age:
up to 2 years: 50-100 mg per day;
2-5 years: 50-150 mg per day;
5-10 years: 100-200 mg per day.
over 10 years: 50-200 mg 1-2 times a day.
Adults
Inside after a meal, 50-200 mg 1-2 times a day.
The highest daily dose: 400 mg.
The highest single dose: 200 mg.
Side effects:Central and peripheral nervous system: dizziness, drowsiness, paresthesia; paradoxical reactions in children - irritability, sleep disturbance, tremor.
Hemopoietic system: granulocythemia, agranulocytosis.
Digestive system: heartburn, nausea, dry mouth, vomiting, epigastric pain, constipation.
Sense organs: blurred vision.
urinary system: dysuria.
Allergic reactions.
Overdose:Drowsiness, confusion, oppression of the central nervous system, coma.
Treatment is symptomatic.
Interaction:With simultaneous application increases the inhibitory effect on the central nervous system of sedatives and ethanol.
Special instructions:Incompatible with ethanol.
When taking the drug is not recommended driving and working with moving machinery.