Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):ONLS
АТХ:V.07.A.C Aids for blood transfusion
Pharmacodynamics:The preservative for the storage of red blood cells and donor blood has an anticoagulant effect, due to which the red blood cells are not "glued". The effect is achieved by binding of calcium cations to citrate anions.
Support for the supply of red blood cells is provided by the dextrose contained in the preparation.
Sodium dihydrogen phosphate, acting as a buffer system, maintains the acid-base balance of the patient's solution and blood after the transfusion procedure.
Pharmacokinetics:The half-life is 14.8 hours. After treatment in the liver, the drug is excreted from the body with urine and feces.
Indications:Conservation of donor blood, production of erythrocyte mass.
XX.Y40-Y59.Y44.6 Native blood and blood products
XX.Y83-Y84.Y83.9 Surgical operation, unspecified
Contraindications:Individual intolerance.
Hemorrhagic syndrome associated with the activation of fibrinolysis.
Carefully:It is not recommended to use the development of DIC-syndrome in the stage of fibrinolysis.
Pregnancy and lactation:Pregnancy and lactation: safety by FDA not determined. The drug in breast milk is not found.
Dosing and Administration:Dilution with canning of donor blood: 14 ml of solution per 100 ml of blood.
For the production of erythrocyte mass: 33 ml of solution per 100 ml of erythrocytic mass.
The drug is added during the delivery of blood and after it in accordance with the specified proportions.
For newborns, small containers with erythrocyte mass are used without compromising health.
Dilution time:
- within 8 hours after blood sampling;
- within 72 hours in those cases when donor blood is frozen after delivery.
Shelf life - 42 days after manufacturing.
Side effects:Allergic reactions, chills, nausea.
With rapid administration (at a rate of more than 5 ml / min), the drug has a nephrotoxic effect.
When transfusion of cold blood solutions develops hypothermia, which provokes arrhythmia and intensification of hypoxia.
Interaction:Transfusion of any blood components with other medicinal substances in one bottle is prohibited!
Special instructions:Do not use a cloudy solution, regardless of shelf life.
The marking of the main line must coincide with the marking on the container.
Before transfusion of blood components, the solution should be warmed up to 37 degrees.
The primary and secondary containers should be centrifuged and mixed thoroughly with the solution.
It is necessary to prepare several blood samples for the determination of group and Rh-accessory, as well as for conducting a test for biocompatibility.