Active substanceUmifenovirUmifenovir
Similar drugsTo uncover
  • Arbidol®
    powder inwards 
    OTISIFARM, OJSC     Russia
  • Arbidol®
    capsules inwards 
  • Arbidol®
    pills inwards 
  • Arbidol®
    pills inwards 
    MASTERLEC, CJSC     Russia
  • Arbidol® Maximum
    capsules inwards 
  • Afludol®
    pills inwards 
  • Dosage form: & nbspfilm-coated tablets
    Composition:Composition for a dosage of 50 mg
    1 tablet contains:

    Active substance: umifenovir hydrochloride monohydrate in terms of umifenovir hydrochloride - 0,0500 g.
    Excipients: lactose monohydrate 0,0861 g, povidone K-25 (polyvinyl pyrrolidone medium molecular weight) 0.0032 g, crospovidone 0.0047 g, silicon dioxide colloid (aerosil) 0.0045 g, magnesium stearate 0.0015 g.
    Shell accessories: opedrai II white [lactose monohydrate - 36%, g-promellose - 28%, titanium dioxide - 26%, macrogol-4000 (polyethylene glycol 4000) -10%] - 0.0060 g.
    Composition for the dosage of 100 mg
    1 tablet contains:
    Active substance:
    umifenovir hydrochloride monohydrate in terms of umifenovir hydrochloride - 0.1000 g;
    Excipients: lactose monohydrate 0.1722 g. povidone K-25 (polyvinylpyrrolidone medium molecular weight) 0.0064 g, crospovidone 0.0094 g, silicon dioxide colloid (aerosil) 0.0090 g, magnesium stearate 0.0030 g.
    Shell accessories: opedrai II white [lactose monohydrate - 36%, g-promellose - 28%, titanium dioxide - 26%, macrogol-4000 (polyethylene glycol 4000) -10%] - 0.0120 g.
    Description:Round biconvex tablets, covered with a film membrane from white to white with a cream shade of color, rough, on a break from white to white with a greenish-yellowish or cream shade of color.
    Pharmacotherapeutic group:An antiviral agent.
    ATX: & nbsp

    J.05.A.X.13   Umifenovir

    Pharmacodynamics:An antiviral agent. Specifically suppresses influenza A and B viruses, coronavirus associated with severe acute respiratory syndrome (SARS). By the mechanism of antiviral action refers to the inhibitors of fusion (fusion), interacts with the hemagglutinin of the virus and prevents the fusion of the lipid envelope of the virus and cell membranes. Has a moderate immunomodulatory effect. Has interferon-inducing activity, stimulates humoral and cellular immunity reactions. phagocytic function of macrophages, increases the stability of the organism against viral infections. Reduces the incidence of complications associated with a viral infection. as well as exacerbations of chronic bacterial diseases.
    Therapeutic efficacy in viral infections is manifested in a decrease in the severity of general intoxication and clinical phenomena, reducing the duration of the disease, reducing the risk of complications.
    Refers to low-toxic drugs (LD50> 4 g / kg). Does not have any negative effects on the human body when administered orally at recommended doses.
    Pharmacokinetics:Absorption is fast. Quickly distributed to organs and tissues. Time to reach the maximum concentration when taken in a dose of 50 mg - 1.2 h, a dose of 100 mg - 1.5 hours Meta-bolziruetsya in the liver. The half-life is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in an insignificant number of kidneys (0.12%). During the first day, 90% of the administered dose is withdrawn.
    Indications:

    Prevention and treatment in adults and children: influenza A and B, other SARS.

    Complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection.

    Prevention of postoperative infectious complications.

    Contraindications:Hypersensitivity to umifenovir or any component of the drug, lactase deficiency, lactose intolerance, glucose-galactose malabsorption,children under 3 years.
    Dosing and Administration:

    Inside, before eating.

    Single dose (depending on age):

    Age

    Single dose of the drug

    from 3 to 6 years

    50 mg (1 tablet of 50 mg)

    from 6 to 12 years

    100 mg (2 tablets of 50 mg or 1 tablet of 100 mg)

    over 12 years and adults

    200 mg (4 tablets of 50 mg or 2 tablets of 100 mg)

    Indication

    Scheme of drug administration

    In children from 3 years of age and adults:

    Nonspecific prevention during the epidemic of influenza and other ARVI

    in a single dose 2 times a week for 3 weeks.

    Nonspecific prophylaxis in direct contact with patients with influenza and other ARVI

    in a single dose once a day for 10-14 days.

    Treatment of influenza and other ARVI

    per day (every 6 hours) for 5 days.

    Complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection

    in a single dose 4 times in a single dose 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks.

    Preventive maintenance after operational infectious complications

    in a single dose for 2 days before the operation, then on days 2 and 5 after the operation.

    Side effects:Rarely, allergic reactions.
    Overdose:Not checked.
    Interaction:In the appointment with other drugs, no negative effects were noted.
    Special instructions:
    Effect on the ability to drive transp. cf. and fur:It does not show central neurotropic activity and can be used in medical practice for preventive purposes in practically healthy persons of various professions, including those requiring increased attention and coordination of movements (transport drivers, operators, etc.).
    Form release / dosage:Tablets, film-coated 50 mg and 100 mg.
    Packaging:10 tablets per contour cell pack. 1, 2. 4 contour mesh packs together with instructions for use are placed in a pack of cardboard.
    Storage conditions:At a temperature of no higher than 25 ° C. Keep out of the reach of children.
    Shelf life:2 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:LP-003474
    Date of registration:26.02.2016 / 24.08.2017
    Expiration Date:26.02.2021
    The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp24.11.2017
    Illustrated instructions
      Instructions
      Up