Active substanceUmifenovirUmifenovir
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    MASTERLEC, CJSC     Russia
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  • Dosage form: & nbspcapsules
    Composition:

    Active substance: arbidol (in terms of anhydrous substance) - 50 mg or 100 mg.

    Excipients: potato starch, microcrystalline cellulose, silicon dioxide colloid (aerosil), crospovidone (kollidone 25), calcium stearate.

    Capsules hard gelatinous.

    titanium dioxide (E 171), quinoline yellow (E 104), ^ / dye sunset, yellow, methyl hydroxybenzoate, propylhydroxybenzoate, acetic acid, gelatin

    Or hard gelatin capsules

    titanium dioxide (E 171), yellow quinoline (E 104), yellow sunset (E 110), gelatin.

    Description:

    Dosage 50 mg - capsule number 3 yellow; dosage of 100 mg - capsules №1 white, cap of yellow color. Content of capsules is a mixture containing granules and powder from white to white with a greenish-yellowish or creamy shade of color.

    Pharmacotherapeutic group:Antiviral and immunostimulating agent
    ATX: & nbsp

    J.05.A.X.13   Umifenovir

    Pharmacodynamics:

    An antiviral agent, has an immunomodulatory and anti-influenza action, specifically suppresses influenza A and B viruses, severe acute respiratory syndrome (SARS). Prevents contact and penetration of viruses into the cell, suppressing the fusion of the lipid envelope of the virus with cell membranes. It has an interferon-inducing action, stimulates humoral and cellular immunity reactions, phagocytic function of macrophages, increases the body's resistance to viral infections. Reduces the incidence of complications associated with a viral infection, as well as exacerbations of chronic bacterial diseases.

    Therapeutic efficacy in viral infections is manifested in a decrease in the severity of general intoxication and clinical phenomena, and in reducing the duration of the disease.

    Refers to low-toxic drugs (LD50 > 4 g / kg). Does not have any negative effects on the human body when administered orally at recommended doses.

    Pharmacokinetics:Quickly absorbed and distributed to organs and tissues. The maximum concentration in blood plasma when taken in a dose of 50 mg is achieved after 1.2 hours, at a dose of 100 mg - after 1.5 hours Metabolized in the liver. The half-life is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in an insignificant number of kidneys (0.12%). During the first day, 90% of the administered dose is withdrawn.
    Indications:

    Prevention and treatment in adults and children:

    - influenza A and B, acute respiratory syndrome, severe acute respiratory syndrome (SARS) (including those complicated by bronchitis, pneumonia);

    - secondary immunodeficiency states;

    - complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection.

    Prevention of postoperative infectious complications and normalization of the immune status.

    Complex therapy of acute intestinal infections of rotavirus etiology in children older than 3 years.

    Contraindications:

    Hypersensitivity to the drug, age to 3 years.

    Dosing and Administration:

    Inside, before eating. Single dose: children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg).

    For non-specific prevention:

    In direct contact with patients with influenza and other SARS:

    - children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg once a day for 10-14 days.

    During the epidemic of influenza and other acute respiratory infections, to prevent exacerbations of chronic bronchitis, recurrence of herpetic infection:

    - children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg twice a week for 3 weeks.

    For prevention of SARS (when in contact with a patient):

    - Adults and children over 12 years of age are prescribed 200 mg once a day. Children from 6 to 12 years of 100 mg once a day (before meals) for 12-14 days.

    Prevention of postoperative complications:

    - children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg for 2 days before the operation, then 2 and 5 days after the operation.

    For treatment.

    Flu, other SARS without complications:

    - children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 4 times a day (every 6 hours) for 5 days.

    Influenza, other acute respiratory infections with complications (bronchitis, pneumonia, etc.).

    - children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 4 times a day (every 6 hours) for 5 days, then a single dose once a week for 4 weeks.

    Severe Acute Respiratory Syndrome (SARS):

    - children over 12 years and adults - 200 mg 2 times a day for 8-10 days.

    In the complex treatment of chronic bronchitis, herpes infection:

    - children from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years and adults - 200 mg 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week within 4 weeks.

    Complex therapy of acute intestinal infections of rotavirus etiology in children older than 3 years:

    - from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years - 200 mg 4 times a day (every 6 hours) for 5 days.

    Side effects:

    Rarely, allergic reactions.

    Overdose:Not checked.
    Interaction:

    In the appointment with other drugs, no negative effects were noted.

    Special instructions:
    Effect on the ability to drive transp. cf. and fur:It does not show central neurotropic activity and can be used in medical practice for preventive purposes in practically healthy persons of various professions, incl. requiring increased attention and coordination of movements (drivers of transport, operators, etc.).
    Form release / dosage:

    Capsules 50 mg and 100 mg.

    Packaging:

    For 5 or 10 capsules in a contour mesh package.

    1, 2 or 4 contour packs with instructions for use in a pack of cardboard.
    Storage conditions:Keep out of the reach of children.
    Shelf life:2 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:P N003610 / 01
    Date of registration:10.05.2007 / 22.08.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:PHARMSTANDART-FORESTRY, OJSC PHARMSTANDART-FORESTRY, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp17.10.2017
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